| receptors, IgE | Specific molecular sites on the surface of b- and T-lymphocytes which combine with iges. Two subclasses exist: low affinity receptors (fc epsilon ri) and high affinity receptors (fc epsilon rii). (12 Dec 1998) |
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| receptors, IgG | Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with iggs. Three subclasses exist: fc gamma ri (the CD64 antigen, a low affinity receptor), fc gamma rii (the CD32 antigen, a high affinity receptor), and fc gamma riii (the CD16 antigen, a low affinity receptor). (12 Dec 1998) |
| receptors, immunologic | Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behaviour of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere. (12 Dec 1998) |
| receptors, insulin | Cell surface proteins that bind insulin and trigger intracellular changes which influence the behaviour of cells. The best understood physiological consequence of insulin receptor activation is increased transport of glucose into most cells, which controls the rate of carbohydrate metabolism. The insulin receptor is a multifunctional protein complex that has intrinsic tyrosine kinase activity and is capable of autophosphorylation. (12 Dec 1998) |
| receptors, insulin-like-growth factor I | Specific proteins on or in cells to which insulin-like growth factor I (somatomedin c) binds and thereby modifies the function of the cells. These receptors contain transmembrane and cytosolic domains, bind igf-I preferentially, and have high-affinity sites for igf-II. The alpha-subunit has a mw of 130 kD and the beta subunit possesses tyrosine kinase activity. (12 Dec 1998) |
| receptors, insulin-like-growth-factor II | Specific proteins on or in cells to which insulin-like growth factor II and mannose-6-phosphate bind and thereby modify the function of the cells. These receptors have a mw of 250 kD and possess no tyrosine kinase activity. (12 Dec 1998) |
| receptors, interferon | Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. Alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system. (12 Dec 1998) |
| receptors, interleukin | Cell surface proteins that bind interleukins and trigger intracellular changes influencing the behaviour of cells. (12 Dec 1998) |
| receptors, interleukin-1 | Specific molecular sites or structures on cells with which interleukin-1 reacts or to which it binds to modify the function of the cells. The il-1 receptor on T-lymphocytes and fibroblasts is composed of a single polypeptide chain that binds both il-1 alpha and il-1 beta. The molecular weight of this high-affinity receptor is believed to be 80 kD. (12 Dec 1998) |
| receptors, interleukin-2 | Receptors present on activated t- and B-cells as a complex consisting of a 55 kD peptide, which reacts with the anti-tac monoclonal antibody, and a 75 kD non-tac interleukin-2-binding peptide. The receptor is present in two forms, one with a very high affinity and the other with low affinity for il-2. The high-affinity form appears to mediate exclusively the growth-promoting response to il-2. The receptor is present in large numbers on resting HTLV-I leukaemia cells, but not on normal resting cells. (12 Dec 1998) |
| receptors, interleukin-3 | Phosphotyrosine-containing proteins, mw 140 kD. They form a stable complex with interleukin-3 with an apparent mass of 170 kD. They are found on a variety of cells and activate interleukin-3. (12 Dec 1998) |
| receptors, interleukin-4 | Receptors present on a wide variety of haematopoietic and non-haematopoietic cell types and various human tumours. Two forms of the receptor have been described, soluble and membrane-bound. Low affinity and high affinity receptors for il-4 have been reported. (12 Dec 1998) |
| receptors, interleukin-6 | <chemical> Receptors present on t cells, mitogen-activated B-cells, peripheral monocytes, and some macrophage- and B-cell-derived tumour cell types. The receptor is a strongly glycosylated protein of 80 kD and a length of 468 amino acids. Pharmacological action: growth inhibitors. (12 Dec 1998) |
| receptors, invertebrate peptide | Cell surface receptors for invertebrate peptide hormones or neuropeptides. (12 Dec 1998) |
| receptors, kainic acid | Cell surface proteins that bind glutamate and directly gate ion channels. Kainic acid receptors were originally discriminated from other glutamate receptors by their affinity for the agonist kainic acid. Activation of kainic acid receptors is generally excitatory to cells. Subtypes have been cloned, and for some the traditional distinction from ampa receptors may not apply. (12 Dec 1998) |
Synonyms : Calcitonin Receptor, Receptor, Calcitonin
Synonyms : CGRP Receptor, Calcitonin-Gene Related Peptide Receptor, Calcitonin Gene Related Peptide Receptor, Calcitonin Gene Related Peptide Receptors, Receptor, CGRP, Receptors, Calcitonin Gene Related Peptide
Synonyms : 1, 25-Dihydroxycholecalciferol Receptor, 1, 25-Dihydroxycholecalciferol Receptors, 1, 25-Dihydroxyvitamin D 3 Receptor, 1, 25-Dihydroxyvitamin D3 Receptor, 1, 25-Dihydroxyvitamin D3 Receptors, Calcitriol Receptor, Receptors, 1, 25-Dihydroxyvitamin D 3
Synonyms : CASR Protein, Ca-Sensing Receptors, Ca2+-Sensing Receptor, Calcium Receptors, Calcium-Sensing Receptor Protein, Calcium-Sensing Receptors, Extracellular Calcium-Ion Sensing Receptor, Parathyroid Calcium-Sensing Receptor, Receptor, Ca-Sensing, Receptors, Calcium
Synonyms : Marijuana Receptor, Receptor, Cannabinoid, Receptor, Marijuana