| POI | a mutation due to an intramolecular reorganization of a gene |
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| POI | the mathematical value toward which a function goes as the independent variable approaches infinity |
| POI | (astronomy) the point in an orbit farthest from the body being orbited |
| POI | a port where customs officials are stationed to oversee the entry and exit of people and merchandise |
| POI | a concern that seriously reflects on your honor |
| POI | a point where lines intersect |
| POI | a line that when crossed permits of no return and typically results in irrevocable commitment |
| POI | a question as to whether the current proceedings are allowed by parliamentary procedure |
| POI | (astronomy) the point in as orbit closest to the body being orbited |
| POI | an indicator that orients you generally |
| POI | the spatial property of the position from which something is observed |
| POI | a mental position from which things are viewed |