| GCGR | glucagon receptor; glucocorticoid receptor |
|---|---|
| INSRR | insulin receptor-related receptor |
| IRR | insulin receptor-related receptor; intrarenal reflux |
| IRS | immunoreactive secretion; infrared spectrophotometry; insulin receptor species; insulin receptor sub... |
| DEUV | direct electronic urethrocystometry |
| nuclear sclerosis | Increased refractivity of the central portion of the lens of the eye. See: nuclear cataract. (05 Mar 2000) |
|---|---|
| nuclear spindle | See: spindle and mitosis. (18 Nov 1997) |
| nuclear stain | <technique> A stain for cell nuclei, usually based on the binding of a basic dye to DNA or nucleohistone. (05 Mar 2000) |
| nuclear transplantation | <procedure> Experimental approach in study of nucleo cytoplasmic interactions, in which a nucleus is transferred from one cell to the cytoplasm (which may be anucleate) of a second. (18 Nov 1997) |
| nuclear transport | <cell biology> Passage of molecules in and out of the nucleus, presumably via nuclear pores. Passage of proteins into the nucleus may depend on possession of a nuclear location sequence containing five consecutive positively charged residues PKKKRKV). (18 Nov 1997) |
| nuclear warfare | Warfare involving the use of nuclear weapons. (12 Dec 1998) |
| nucleolar-nuclear ratio | Ratio of volume of nucleolus to volume of nucleus, usually increased in malignant neoplasms. (05 Mar 2000) |
| direct nuclear division | <cell biology> An unusual form of nuclear division, in which the nucleus simply constricts, rather like a cell without chromosome condensation or spindle formation. Partitioning of daughter chromosomes is haphazard. Observed in some Protozoa. (18 Nov 1997) |
| indirect nuclear division | <cell biology> A method of indirect division of a cell, consisting of a complex of various processes, by means of which the two daughter nuclei normally receive identical complements of the number of chromosomes characteristic of the somatic cells of the species. Mitosis, the process by which the body grows and replaces cells, is divided into four phases. 1. Prophase: formation of paired chromosomes, disappearance of nuclear membrane, appearance of the achromatic spindle, formation of polar bodies. 2. Metaphase: arrangement of chromosomes in the equatorial plane of the central spindle to form the monaster. Chromosomes separate into exactly similar halves. 3. Anaphase: the two groups of daughter chromosomes separate and move along the fibres of the central spindle, each toward one of the asters, forming the diaster. 4. Telophase: the daughter chromosomes resolve themselves into a reticulum and the daughter nuclei are formed, the cytoplasm divides, forming two complete daughter cells. NOTE: the term mitosis is used interchangeably with cell division, but strictly speaking it refers to nuclear division, whereas cytokinesis refers to division of the cytoplasm. In some cells, as in many fungi and the fertilized eggs of many insects, nuclear division occurs within the cell unaccompanied by division of the cytoplasm and formation of daughter cells. (13 Nov 1997) |
| internal nuclear layer of retina | The intermediate layer of neurons in the retina composed largely of bipolar cells. Synonym: internal nuclear layer of retina, stratum ganglionare retinae, stratum nucleare internum retinae. (05 Mar 2000) |
| epstein-barr virus nuclear antigens | Nuclear antigens encoded by epstein-barr virus genes. at least six nuclear antigens have been identified but their mechanism of action and role in B-cell transformation is still unknown. (12 Dec 1998) |
| external nuclear layer of retina | The outermost layer of the cerebral layer of retina, composed of the primary receptor cells of the retina; the stratum consists of two sublayers: 1) an external layer made up of the rods and cones, the photosensitive processes of the receptor cells, and 2) the external nuclear layer containing the cell bodies of these cells; the external limiting membrane forms a perforated supporting plate between the two sublayers; the name refers to the fact that the retinal receptor cells are a specialised form of (epithelial) ependyma cell and thus, in a sense, are comparable to the neuroepithelial cells (e.g., hair cells) of other sense organs. Synonym: external nuclear layer of retina, stratum neuroepitheliale retinae, stratum nucleare externum retinae. (05 Mar 2000) |
| U1 small nuclear RNA-(guanosine-N2)-methyltransferase | <enzyme> A trans-active non-small nuclear ribonucleoprotein; facilitates the formation of the m3g cap Registry number: EC 2.1.1.- Synonym: u1 snrna(g-n2)mtase (26 Jun 1999) |
| U6 small nuclear RNA methyltransferase | <enzyme> Methylates gamma-phosphate residues in rnas; distinct from u6 snrna n6-adenosine methyltranferase; mw 130 kD; from hela cells Registry number: EC 2.1.1.- Synonym: u6 snrna capping enzyme (26 Jun 1999) |
| acetylcholine receptor antibodies | <neurology, investigation> A test used to measure the amount of antibodies to acetylcholine receptors on nerve endings. This is a diagnostic test for myasthenia gravis. A normal value is no antibodies in the bloodstream. Acetylcholine receptor (AChR) binding autoantibodies (i.e. Antibodies reactive with several epitopes other than the binding site for acetylcholine or alpha-bungarotoxin) are present in approximately 88% of patients with generalised myasthenia gravis, 70% of ocular myasthenia and in approximately 80% of myasthenia gravis in remission. Although serum concentrations of AChR binding autoantibodies do not in general correlate well with severity of weakness, there is typical decrease in concentration as weakness improves with immunosuppressive therapy. AChR blocking autoantibodies (i.e., antibodies reactive with the AChR binding site) are present in about 50% of patients with myasthenia gravis, 30% with ocular myasthenia gravis and 20% of myasthenia gravis in remission, AChR blocking autoantibodies are the only AChR autoantibodies present in about 1% of myasthenia gravis. AChR modulating autoantibodies (i.e., autoantibodies which cross-link AChRs and cause their removal from muscle membrane surfaces) are present in more than 90% of myasthenia gravis and occasionally are the only AchR autoantibodies detectable in mild, recent onset or ocular-restricted myasthenia gravis. Results for AChR modulating autoantibodies can be transiently false-positive due to curare-like drugs used during general anesthesia. AChR autoantibodies of one or more types are found in at least 80% of ocular myasthenia gravis. Although generally absent in neurological conditions other than myasthenia gravis(and consequently unlikely to cause confusion in neurodiagnosis), false-positive results for AChR autoantibodies occasionally occur in primary biliary cirrhosis, tardive dyskinesia, autoimmune thyroiditis, the elderly, amyotrophic lateral sclerosis patients treated with cobra venom and patients with thymoma in the absence of myasthenia gravis. Approximately 1% of patients with rheumatoid arthritis treated with D-penicillamine develop AChR autoantibodies and myasthenia gravis, both of which disappear when the drug is discontinued. Babies born to ~10% of myasthenia gravis mothers have a transient neonatal form of myasthenia gravis that responds well to anticholinesterase therapy and usually remits within 1 month as maternal IgG disappears. (29 Dec 1997) |