| mucolipidosis I | <biochemistry> Mucolipidosis somewhat like a mild form of Hurler's syndrome with mild dysostosis multiplex, and moderate mental retardation due to neuraminidase deficiency. Inheritance: autosomal recessive. Synonym: lipomucopolysaccharidosis. (05 Mar 2000) |
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| mucolipidosis II | <biochemistry> Mucolipidosis of early onset and with severe symptoms like those in Hurler's syndrome but with normal urinary mucopolysaccharides, vacuolated lymphocytes, and inclusion bodies in cultured fibroblasts (I-cells). The lysosomes lack hydrolases but high concentrations of lysosomal enzymes are found in the extracellular fluids such as serum, spinal fluid, and urine. It is associated with a deficiency of N-acetylglucosaminyl-1-phosphotransferase. The gene defect responsible probably prevents the addition of the lysosome recognition marker mannose 6 phosphate) to these enzymes so that they are not directed into the lysosomes but are released. Inheritance: autosomal recessive. Synonym: I-cell disease, inclusion cell disease. (12 Jul 2000) |
| mucolipidosis III | <biochemistry> Mucolipidosis with mild Hurler-like symptoms, restricted joint mobility, short stature, mild mental retardation, and dysplastic skeletal changes, especially of the hip. Aortic and mitral valve disease are often present. It is associated with a deficiency of UDP-N-acetyl glucosamine and lysosomal enzyme N-acetylglucosaminyl-1-phosphotransferase. Inheritance: autosomal recessive. Synonym: pseudo-Hurler polydystrophy, pseudopolydystrophy. (05 Mar 2000) |
| mucolipidosis IV | <biochemistry> Psychomotor retardation with cloudy corneas and retinal degeneration, with inclusion cells in cultured fibroblasts; may be due to a deficiency of neuramidase, but details are uncertain. Inheritance: autosomal recessive. (05 Mar 2000) |
| mucolysis | The solution, digestion, or liquefaction of mucus. Origin: muco-+ G. Lysis, dissolution (05 Mar 2000) |
| mucolytic | Destroying or dissolving mucin, an agent that so acts: a mucopolysaccharide or glycoprotein, the chief constituent of mucus. Origin: Gr. Lysis = dissolution (18 Nov 1997) |
| mucomembranous | Relating to a mucous membrane. (05 Mar 2000) |
| mucomembranous enteritis | An affection of the intestinal mucous membrane characterised by constipation or diarrhoea (sometimes alternating), colic, and the passage of pseudomembranous shreds or incomplete casts of the intestine. Synonym: mucoenteritis. (05 Mar 2000) |
| muconate | <chemistry> A salt of muconic acid. Source: Websters Dictionary (01 Mar 1998) |
| muconate cycloisomerase | <enzyme> Do not confuse with 3-carboxy-cis,cis-muconate lactonizing enzyme Chemical name: 4-carboxy- methyl-4-hydroxyisocrotonolactone lyase(decycling) Registry number: EC 5.5.1.1 Synonym: cis,cis-muconate lactonizing enzyme, cis, cis-muconate cyclase (26 Jun 1999) |
| muconic | <chemistry> Of, pertaining to, or designating, an organic acid, obtained indirectly from mucic acid, and somewhat resembling itaconic acid. Origin: Mucic + itaconic. Source: Websters Dictionary (01 Mar 1998) |
| muconolactone delta-isomerase | <enzyme> Catalyses the conversion of 4-hydroxy-4-carboxymethylisocrotonolactone to 3-oxoadipate enol-lactone; minor descriptor (75-83); on-line and index medicus search isomerases (75-83) Registry number: EC 5.3.3.4 (26 Jun 1999) |
| mucopeptide | <protein> Synonym for peptidoglycan. (18 Nov 1997) |
| mucopeptide glycohydrolase | <cell biology, enzyme> Glycosidase that hydrolyses the bond between N acetyl muramic acid and N acetyl glucosamine, thus cleaving an important polymer of the cell wall of many bacteria. Present in tears, saliva and in the lysomes of phagocytic cells, it is an important antibacterial defence, particularly against gram-positive bacteria. (18 Nov 1997) |
| mucoperichondrial flap | A flap composed of mucosa and perichondrium, as from the nasal septum. (05 Mar 2000) |