| fibrinogenous | <physiology> Possessed of properties similar to fibrinogen; capable of forming fibrin. Pertaining to fibrinogen, producing fibrin. (12 May 2002) |
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| fibrinogens, abnormal | Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilised fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenaemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing. (12 Dec 1998) |
| fibrinoid | 1. Resembling fibrin. 2. A deeply or brilliantly acidophilic, homogeneous, refractile, proteinaceous material that: 1) is frequently formed in the walls of blood vessels and in connective tissue of patients with such diseases as disseminated lupus erythematosus, polyarteritis nodosa, scleroderma, dermatomyositis, and rheumatic fever; 2) is sometimes observed in healing wounds, chronic peptic ulcers, the placenta, necrotic arterioles of malignant hypertension, and other unrelated conditions. Origin: fibrin + G. Eidos, resemblance (05 Mar 2000) |
| fibrinoid necrosis | Necrosis in which the necrotic tissue has some staining reactions resembling fibrin and becomes deeply eosinophilic, homogenous, and refractile. (05 Mar 2000) |
| fibrinokinase | Name proposed for the enzyme that converts plasminogen to plasmin; subsequently called urokinase, but now called plasminogen activator. Synonym: fibrinolysokinase. (05 Mar 2000) |
| fibrinolysin | Synonym: plasmin. (05 Mar 2000) |
| fibrinolysis | <haematology> Solubilisation of fibrin in blood clots, chiefly by the proteolytic action of plasmin. Origin: Gr. Lysis = dissolution (12 Nov 1997) |
| fibrinolysokinase | Name proposed for the enzyme that converts plasminogen to plasmin; subsequently called urokinase, but now called plasminogen activator. Synonym: fibrinolysokinase. (05 Mar 2000) |
| fibrinolytic | Pertaining to, characterised by or causing the dissolution of fibrin by enzymatic action Origin: Gr. Lysis = dissolution (18 Nov 1997) |
| fibrinolytic agent | Fibrinolysin or agents that convert plasminogen to fibrinolysin. They may be endogenous or exogenous like the bacterial enzymes used in thromboembolism. (12 Dec 1998) |
| fibrinolytic purpura | Purpura in which the bleeding is associated with rapid fibrinolysis of the clot. (05 Mar 2000) |
| fibrinopeptide | <protein> Very negatively charged peptide fragments cleaved from fibrinogen by thrombin. Two peptides (A and B) are produced from each fibrinogen molecule. A: This is released as a part of the clotting process. Increased levels may be seen in DIC, lupus, cellulitis and leukaemia. (09 Oct 1997) |
| fibrinopeptide a | Two small peptide chains removed from the n-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide a is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin. (12 Dec 1998) |
| fibrinopeptide b | Two small peptide chains removed from the n-terminal segment of the beta chains of fibrinogen by the action of thrombin. Each peptide chain contains 20 amino acid residues. The removal of fibrinopeptides b is not required for coagulation. (12 Dec 1998) |
| fibrinoplastic | <physiology> Like fibrinoplastin; capable of forming fibrin when brought in contact with fibrinogen. Source: Websters Dictionary (01 Mar 1998) |