| tubulin-tyrosine ligase | <enzyme> An enzyme that covalently links a tyrosine to the C-terminal glutamyl residue of tubulin, coupled with the hydrolysis of ATP to ADP and Pi; this is a unique posttranslational modification that may have a significant role in cytoskeletal traffic and design. (05 Mar 2000) |
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| tyrosine-trna ligase | <enzyme> An enzyme that activates tyrosine with its specific transfer RNA. Chemical name: L-Tyrosine:tRNA-(Tyr) ligase (AMP-forming) Registry number: EC 6.1.1.1 (12 Dec 1998) |
| tyrosyltubulin ligase | <enzyme> Catalyses reversible, post-translational addition of tyrosine, phenylalanine or dopa to carboxyl terminal of alpha-chain of tubulin Registry number: EC 6.3.2.- Synonym: tubulin-tyrosine ligase, tyrosyl tubulin ligase (26 Jun 1999) |
| ubiquitin-calmodulin ligase | <enzyme> Covalentyl links ubiquitin to bovine calmodulin in an ATP-dependent manner Registry number: EC 6.3.2.21 Synonym: ubiquityl-calmodulin synthetase (26 Jun 1999) |
| ubiquitin-protein ligase | <enzyme> Consists of 3 enzymes; e1 is ubiquitin activating enzyme; e2 transfers activated ubiquitin as an enzyme-ubiquitin thiol ester to e3, which transfers ubiquitin to an intracellular protein; e1 forms both an enzyme-bound cooh-terminal ubiquitin thiolester and a cooh-terminal ubiquitin-adenylatte; ube1y is putative y function in spermatogonial proliferation; ube1x and ube1y encode the e1 enzyme Registry number: EC 6.3.2.19 Synonym: ubiquitin-protein ligase system, ubiquitin-protein-lysine n-omega-ligase, ubiquitin-activating enzyme, ubiquitin-activating enzyme e1, ubiquitination activating enzyme e1, ube1 gene product, rsp5 ubiquitin-protein ligase, npi1 protein, ube1y gene product, ube1x gene product, ikappab-ubiquitin ligase (26 Jun 1999) |
| UDP-N-acetylmuramoylalanine-D-glutamate ligase | <enzyme> From E coli; catalyses the synthesis of udp-n-acetylmuramoyl-l-alanyl-d-glutamate from ATP and udp-n-acetylmuramoyl-l-alanine and d-glutamate Registry number: EC 6.3.2.9 Synonym: d-glu-adding enzyme, d-glutamic acid adding enzyme, murd gene product (26 Jun 1999) |
| UDP-N-acetylmuramoylalanyl-glutamyl-2,6-diaminopimelate-alanyl-alanine ligase | <enzyme> Reaction: ATP + udp-n-acetylmuramoyl-l-ala-d-glu-2,6 -diaminoheptanedioate d-ala-d-ala = ADP + orthophosphate + udp-n-acetylmuramoyl-l-ala-d-glu-6-carboxy-l-lys-d-ala-d-ala; 454 amino acids, mw 48 kD; from bacteria; final step in synthesis of udp-n-acetylmuramoyl pentapeptide; genbank x62437 Registry number: EC 6.3.2.15 Synonym: udp-n-acetylmuramoyl-alanyl-d-glutamyl-meso-2,6-diaminopimeloyl-d-alanyl-d-alanine synthetase, murf gene product, udp-n-acetylmuramoyl-l-ala-glu-meso-2,6-diaminopimeloyl-ala-ala synthetase (26 Jun 1999) |
| 2,3-dihydroxybenzoate-AMP ligase | <enzyme> Catalyses the conversion of 2,3-dihydroxybenzoate and ATP to form (2,3-dihydroxybenzoyl)adenylate, this acyladenylate remains bound to the enzyme for further reactions in the overall biosynthesis of enterobactin Registry number: EC 6.5.- Synonym: 2,3dhb-AMP ligase, ente gene product (26 Jun 1999) |
| 2-aminobenzoate coenzyme A ligase | <enzyme> From a denitrifying pseudomonas sp.; catalyses the formation of CoA thioester of 2-aminobenzoate with the formation of AMP and pyrophosphate from ATP Registry number: EC 6.2.1.- Synonym: 2-ab CoA ligase (26 Jun 1999) |
| 3-hydroxypicolinic acid-AMP ligase | <enzyme> From cell extracts of streptomyces pristinaespiralis; activates the first pristinamycin 1 residue 3-hydroxypicolinic acid; shows 58% nh2-terminal amino acid sequence identity with s. Griseoviridus 3-hpa-activating enzyme; amino acid sequence given in first source (page 709) Registry number: EC 6.3.2.- Synonym: pi synthetase 1, snba protein, pristinamycin I synthetase 1,3-hpa-AMP ligase (26 Jun 1999) |
| 4-halobenzoate-CoA ligase | <enzyme> Involved in conversion of 4-chlorobenzoate to 4-hydroxybenzoate by pseudomonas sp. Cbs3; 115 kD; acts on 4-chloro-, 4-bromo-, 4-iodobenzoate most effectively; 16 n-terminal amino acid sequence determined, with 3 questions, in first source Registry number: EC 6.2.1.- Synonym: 4-chlorobenzoate-CoA ligase, 4-cba-CoA ligase, 4-chlorobenzoate-coenzyme a ligase (26 Jun 1999) |
| 4-hydroxybenzoate coenzyme A ligase | <enzyme> From rhodopseudomonas palustris; involved in anaerobic metabolism of 4-hydroxybenzoate Registry number: EC 6.2.1.- Synonym: 4-hydroxybenzoate-CoA ligase, 4-hb-CoA ligase (26 Jun 1999) |
| formate-tetrahydrofolate ligase | <enzyme> An enzyme that catalyses the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. This enzyme has been found in pigeon liver, human erythrocytes and some microorganisms. Chemical name: Formate:tetrahydrofolate ligase (ADP-forming) Registry number: EC 6.3.4.3 (12 Dec 1998) |
| leucine-trna ligase | <enzyme> An enzyme that activates leucine with its specific transfer RNA. Chemical name: L-Leucine:tRNA(Leu) ligase (AMP-forming) Registry number: EC 6.1.1.4 (12 Dec 1998) |
| ligase | <enzyme, molecular biology> Major class of enzymes that catalyse the linking together of two molecules (category 6 in the I.U.B.C.E. Nomenclature) for example DNA ligases that link two fragments of DNA by forming a phosphodiester bond. (18 Nov 1997) |