| receptors, thyroid hormone | Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erba, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erba proteins act as growth suppressors. The c-erba proteins are encoded by at least two genes, c-erba alpha and c-erba beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes thyroid hormone resistance syndrome. (12 Dec 1998) |
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| parathyroid hormone | <hormone> A peptide hormone of 84 amino acids (9402 D). Stimulates osteoclasts to increase blood calcium levels, the opposite effect to calcitonin. (18 Nov 1997) |
| glycoprotein hormone-specific N-acetylgalactosamine transferase | <enzyme> Transfers galnac to the terminal glcnac moieties of glcnac2man3glcnac2asn Registry number: EC 2.4.1.- Synonym: ghs-acgalnh2 transferase, glycoprotein hormone galnac transferase, glycoprotein hormone - n-acetylgalactosaminyltransferase (26 Jun 1999) |
| melanocyte-stimulating hormone | <endocrinology> A releasing hormone produced in the mammalian hypophysis and related structures in lower vertebrates. Made up of _ MSH (1665D), the same as amino acids 1-13 of ACTH and _ MSH (18 amino acids, 22 in humans). Causes darkening of the skin by expansion of the melanophores but its role in mammals is unclear. Synonym: melanotropin. Acronym: MSH (22 Sep 2002) |
| melanotropin release-inhibiting hormone | Inhibits synthesis and release of melanotropin. Synonym: melanotropin release-inhibiting hormone. Origin: melanotropin + G. States, stationary, + -in (05 Mar 2000) |
| peptide hormone inactivating endopeptidase | <enzyme> From xenopus laevis; cleaves at xaa-phe, xaa-leu or xaa-ile bonds where xaa = ser, phe, tyr, his or gly in peptide hormones Registry number: EC 3.4.24.- Synonym: phie, xenopus (26 Jun 1999) |
| gonadotropic hormone | <endocrinology, hormone> A hormone capable of promoting gonadal growth and function. The effects are usually limited to discrete functions or histological components of a gonad, such as stimulation of follicular growth or of androgen formation. Most gonadotrophin's exert their effects in both sexes, although the effect of a given gonadotrophin will differ in males and females. Synonym: gonadotropin, gonadotropic hormone. Origin: for gonadotrophin, fr. Gonad + G. Trophe, nourishment (12 Sep 2002) |
| growth hormone | <endocrinology, hormone> Polypeptide (191 amino acids) produced by anterior pituitary that stimulates liver to produce somatomedins 1 & 2. (13 Nov 1997) |
| growth hormone-producing adenoma | <tumour> An adenoma that produces the clinical picture of gigantism or acromegaly, although a third of the cells have no granules or are a mixture of acidophils and chromophobes; some tumours may secrete both growth hormone and prolactin; often an acidophil or eosinophil adenoma. (05 Mar 2000) |
| growth hormone stimulation test | <investigation> A test which measures the level of human growth hormone in response to the administration of the amino acid arginine. This test measures the ability of the pituitary gland to secrete growth hormone. Normal values in children are: 48 ng/ml. Normal values in men are 10 ng/ml. Normal values in women are 15 ng/ml. This test is used to evaluate infants with growth retardation. It may also be part of an evaluation for a pituitary tumour. Failure of arginine to raise growth hormone levels may indicate hypopituitarism or dwarfism. (27 Sep 1997) |
| growth hormone suppression test | <investigation> A test to determine if growth hormone is suppressed by hyperglycaemia. Growth hormone blood levels are determined sequentially after ingestion of a glucose-rich meal. If growth hormone levels remain elevated (after the glucose is given) then acromegaly or gigantism is suspected. (27 Sep 1997) |
| chorionic gonadotrophic hormone | A glycoprotein with a carbohydrate fraction composed of d-galactose and hexosamine, extracted from the urine of pregnant women and produced by the placental trophoblastic cells; its most important role appears to be stimulation, during the first trimester, of ovarian secretion of the oestrogen and progesterone required for the integrity of conceptus; it appears to play no significant role in the last two trimesters of pregnancy, as the oestrogen and progesterone are then formed by the placenta. Synonym: anterior pituitary-like hormone, choriogonadotropin, chorionic gonadotropic hormone, chorionic gonadotrophic hormone, placenta gonadotropin, placentagonadotropin. (05 Mar 2000) |
| chorionic growth hormone-prolactin | human placental lactogen |
| chromatophorotropic hormone | See: melanotropin. (05 Mar 2000) |
| pituitary gonadotropic hormone | Any gonadotropin of hypophysial origin; formerly used to designate a single hormone, because it was thought that the anterior hypophysis secreted only one gonadotropin. Synonym: pituitary gonadotropic hormone. (05 Mar 2000) |