| thrombophilia | A disorder of the haemopoietic system in which there is a tendency to the occurrence of thrombosis. (12 Dec 1998) |
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| thrombophlebitis | <pathology> Inflammation of a vein associated with thrombus formation. Origin: Gr. Phleps = vein. (18 Nov 1997) |
| thromboplastid | Synonym: platelet. 2. A nucleated spindle cell in submammalian blood. Origin: thrombo-+ G. Plastos, formed (05 Mar 2000) |
| thromboplastin | <haematology> Traditional name for substance in plasma that converts prothrombin to thrombin. Now known not to be a single substance. (See thrombin). (18 Nov 1997) |
| thromboplastinogen | A coagulation (clotting) factor. Classic haemophilia (haemophilia A) is due to a congenital deficiency in the amount (or activity) of factor VIII. Factor VIII is also known as antihemophiliac factor (AHF) or antihemophiliac globulin (AHG). The gene for factor VIII (that for classic haemophilia) is on the X chromosome so females can be silent carriers without symptoms and males can be haemophiliacs. (12 Dec 1998) |
| thromboplastinogenaemia | The presence of thromboplastinogen in the circulating blood. Origin: thromboplastinogen + G. Haima, blood (05 Mar 2000) |
| thromboplastinogenase | <enzyme> An enzyme in blood that catalyses the conversion of inactive thromboplastinogen to thromboplastin. (05 Mar 2000) |
| thrombopoiesis | Precisely, the process of a clot forming in blood, but generally used with reference to the formation of blood platelets (thrombocytes). Origin: thrombo-+ G. Poiesis, a making (05 Mar 2000) |
| thrombopoietin | <chemical> A humoral factor that controls blood platelet production through stimulation of megakaryocyte populations. Bone marrow megakaryocytes increase in both size and number in response to exposure to thrombopoietin. Chemical name: Thrombopoietin (12 Dec 1998) |
| thrombosed | 1. Clotted. 2. Denoting a blood vessel that is the seat of thrombosis. (05 Mar 2000) |
| thromboses | Plural of thrombosis. (05 Mar 2000) |
| thrombosin | <enzyme> Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. (18 Nov 1997) |
| thrombosis | <haematology> The formation, development or presence of a thrombus. (14 May 1997) |
| thrombospondin | <cell biology> Homotrimeric glycoprotein (450 kD) from _ granules of platelets and synthesised by various cell types in culture. Also found in extracellular matrix of cultured endothelial, smooth muscle and fibroblastic cells. May have autocrine growth regulatory properties: involved in platelet aggregation. (18 Nov 1997) |
| thrombospondin 1 | An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumour growth and metastasis. (12 Dec 1998) |