| receptors, endothelin | Cell surface proteins that bind endothelin with high affinity and trigger intracellular changes which influence the behaviour of cells. (12 Dec 1998) |
|---|---|
| receptors, epidermal growth factor-urogastrone | Glycoproteins of about 170 kD that have protein kinase activity and span the plasma membranes of growing cells, including tumours. They are activated by the binding of epidermal growth factor-urogastrone which then initiates DNA and protein synthesis. They are not found on mitotically quiescent cells except in the stomach where they control the synthesis and release of digestive enzymes and gastric acid. Transforming growth factor alpha also binds to and activates these receptors. (12 Dec 1998) |
| receptors, erythropoietin | Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behaviour of cells. (12 Dec 1998) |
| receptors, estradiol | Cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate DNA transcription. (12 Dec 1998) |
| receptors, fc | Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognise and combine with the fc (crystallizable) portion of immunoglobulin molecules. (12 Dec 1998) |
| receptors, fibroblast growth factor | Specific molecular sites or structures on cell membranes that react with fibroblast growth factors (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity. (12 Dec 1998) |
| Receptors for activated C Kinase | Synonym for endosome. (18 Nov 1997) |
| receptors, fsh | Cell surface proteins that bind follicle-stimulating hormone (follitropin, fsh) with high affinity and trigger intracellular changes influencing the behaviour of cells. (12 Dec 1998) |
| receptors, gaba | Cell-surface proteins that bind gaba with high affinity and trigger changes that influence the behaviour of cells. Gaba-a receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. Gaba-b receptors act through g-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for l-baclofen. (12 Dec 1998) |
| receptors, gaba-a | Cell surface proteins which bind gaba and control an integral membrane chloride channel. Gaba-a receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5ht-3 receptors. Most gaba-a receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates. (12 Dec 1998) |
| receptors, gaba-b | Cell surface proteins which bind gaba and influence cells via interactions with g-proteins. Gaba-b receptors are pharmacologically characterised by their insensitivity to the blocker bicuculline and sensitivity to the agonist l-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase a2, activation of potassium channels, and inactivation of voltage-activated calcium channels. (12 Dec 1998) |
| receptors, gastrointestinal hormone | Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behaviour of cells. most gastrointestinal hormones also act as neurotransmitters so these receptors are also present in the central and peripheral nervous systems. (12 Dec 1998) |
| receptors, glucagon | Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behaviour of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs. (12 Dec 1998) |
| receptors, glucocorticoid | Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example. (12 Dec 1998) |
| receptors, glutamate | Cell-surface proteins that bind glutamate and trigger changes which influence the behaviour of cells. Glutamate receptors include ionotropic receptors (ampa, kainate, and n-methyl-d-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases. (12 Dec 1998) |