| HLD | hepatolenticular degeneration; herniated lumbar disk; Hippel-Lindau disease; hypersensitivity lung d... |
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| INCD | infantile nuclear cerebral degeneration |
| JMD | juvenile macular degeneration |
| MDT | mast [cell] degeneration test; mean dissolution time; median detection threshold; multidisciplinary ... |
| NFD | neurofibrillary degeneration |
| spongy degeneration of infancy | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
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| nerve degeneration | Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. (12 Dec 1998) |
| neurofibrillary degeneration | Formation of coarse, argentophilic, intracytoplasmic fibres, often in complex tangles within intracranial nerve cells that are undergoing aging. See: Alzheimer's disease. (05 Mar 2000) |
| Nissl degeneration | Degeneration of the cell body occurring after transection of the axon; characterised by dispersion of the granular endoplasmic reticulum, swelling of the soma, and an eccentric position of the nucleus of the cell. (05 Mar 2000) |
| subacute combined degeneration of the spinal cord | A subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterised by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns. Synonym: combined sclerosis, combined system disease, funicular myelitis, Putnam-Dana syndrome, vitamin B12 neuropathy. (05 Mar 2000) |
| degeneration | An effect whereby the productivity of a microbial strain used in a commercial process diminishes after repeated transfer from one culture media to another, often caused by genetic mutation. (14 Nov 1997) |
| descending degeneration | Orthograde (wallerian) degeneration of an injured nerve fibre; i.e., distal to the lesion, degeneration caudal to the level of a spinal cord lesion. (05 Mar 2000) |
| disciform degeneration | Foveal or parafoveal subretinal neovascularization with retinal separation and haemorrhage leading finally to a circular mass of fibrous tissue with marked loss of visual acuity. Synonym: disciform macular degeneration. (05 Mar 2000) |
| disciform macular degeneration | Foveal or parafoveal subretinal neovascularization with retinal separation and haemorrhage leading finally to a circular mass of fibrous tissue with marked loss of visual acuity. Synonym: disciform macular degeneration. (05 Mar 2000) |
| infantile neuronal degeneration | <neurology, paediatrics> Degenerative disorder of infants with widespread neuronal loss in thalamus, cerebellum, pons, and spinal cord, resembling infantile muscular atrophy. (05 Mar 2000) |
| olivopontocerebellar degeneration | <neurology> An inherited disease especially. Of mid to late life that is characterised by ataxia, hypotonia, dysarthria, and degeneration of the cerebellar cortex, middle cerebellar peduncles, and inferior olives. (09 Oct 1997) |
| orthograde degeneration | <medicine> A form of degeneration occurring in nerve fibres as a result of their division; so called from Dr. Waller, who published an account of it in 1850. Source: Websters Dictionary (01 Mar 1998) |
| tapetoretinal degeneration | A hereditary disorder of the retina mainly affecting photoreceptors and retinal pigment epithelium; a miscellaneous category including Friedreich's ataxia, Refsum's disease, and abetalipoproteinaemia. Synonym: primary pigmentary degeneration of retina. (05 Mar 2000) |
| Terrien's marginal degeneration | A form of marginal corneal degeneration. (05 Mar 2000) |
| ectatic marginal degeneration of cornea | Bilateral opacification and vascularization of the periphery of the cornea, progressing to formation of a gutter and ectasia. Synonym: ectatic marginal degeneration of cornea. (05 Mar 2000) |