| n-methyl-3,4-methylenedioxyamphetamine | <chemical> An n-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as mdma or ecstasy. Pharmacological action: adrenergic uptake inhibitors, hallucinogens, serotonin agents. Chemical name: 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl- (12 Dec 1998) |
|---|---|
| N methyl D aspartate receptor | <physiology> Glutamate receptor sub type (see excitatory amino acids). N methyl D aspartate receptor channels seem to be potentiated by intracellular arachidonic acid. Acronym: NMDA (26 Mar 1998) |
| N-methyl, D-aspartic acid | n methyl D aspartate receptor |
| isoprenylcysteine methyl ester hydrolase | <enzyme> Acts on proteins post-translationally isoprenylated on a cysteine 3 amino acids in from the carboxy terminus, followed by carboxymethylation Registry number: EC 3.1.1.- Synonym: isoprenylcys methylase (26 Jun 1999) |
| tosylarginine methyl ester | <chemical> N(2)-(p-tolylsulfonyl)-l-arginine, methyl ester. Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of c(l) on c(4). Chemical name: L-Arginine, N2-((4-methylphenyl)sulfonyl)-, methyl ester (12 Dec 1998) |
| tosylarginine methyl ester hydrolase | <enzyme> Protease from sea urchin (arbacia punctulata) eggs; fertilization in the sea urchin is accompanied by the release of this protease from eggs into the surrounding seawater; enzyme uses tame as substrate; used as a measure of trypsin-like activity; tryptase (formerly here) is mast cell tryptase (EC 3.4.21.59) Registry number: EC 3.4.- Synonym: tame hydrolase, tame esterase, esterase a2, n-tosyl-l-arginine methyl ester esterase, tamase, tamase-1 (26 Jun 1999) |
| 1-methyl-3-isobutylxanthine | <chemical> 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-2,6-dione. A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates cyclic nucleotide-dependent protein kinases. Pharmacological action: phosphodiesterase inhibitors. Chemical name: 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- (12 Dec 1998) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | <chemical> 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine. A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in parkinson disease. These toxic effects can be prevented by the administration of selective monoamine oxidase inhibitors. Since the cellular toxicity of the compound is similar to that observed in idiopathic parkinson disease, experimental studies with this compound can suggest new opportunities for effective therapy. The compound also induces duodenal ulcers. Pharmacological action: dopamine agents. Chemical name: Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl- (12 Dec 1998) |
| 1-methyl-4-phenylpyridinium | <chemical> 1-methyl-4-phenylpyridinium (mpp+). An active neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to paraquat, has also been used as an herbicide. Pharmacological action: dopamine agents, herbicides. Chemical name: Pyridinium, 1-methyl-4-phenyl- (12 Dec 1998) |
| 2-methyl branched-chain enoyl-CoA reductase | <enzyme> Important in the reversal of beta-oxidation under anaerobic conditions in ascaris suum Registry number: EC 1.3.1.52 Synonym: 2-methyl bce-CoA reductase (26 Jun 1999) |
| 3-(2,4--dioxo-6-methyl-5-pyrimidinyl)acrylic acid synthase | <enzyme> Involved in sparsomycin biosynthesis; catalyses conversion of 3-(4-oxo-6-methyl-5-pyrimidinyl)acrylic acid to 3-(2,4-dioxo-6-methyl-5-pyrimidinyl)acrylic acid Registry number: EC 1.14.13.- Synonym: (e)-uca synthase (26 Jun 1999) |
| (3-(5-methyl-2-thienyl)acryloyl)chymotrypsin | Pharmacological action: indicator and reagent Synonym: 3-mtac (26 Jun 1999) |
| 3-methyl-2-oxobutanoate hydroxymethyltransferase | <enzyme> Methylenetetrahydrofolate and alpha-ketoisovalerate gives tetrahydrofolate and ketopantoate Chemical name: 5,10-methylenetetrahydrofolate alpha-ketoisovalerate hydroxymethyltransferase Registry number: EC 2.1.2.11 Synonym: iphm transferase, panb protein, ketopantoate hydroxymethyltransferase (26 Jun 1999) |
| 3-O-methyl-fluorescein phosphatase | <enzyme> Used for assay of na-k-atpase in intact tissues Registry number: EC 3.6.1.- Synonym: 3-o-methylfluorescein phosphatase (26 Jun 1999) |
| (4-fluorophenyl)-alpha-methyl-5-benzoxazole methylamine | Amine derivative of flunoxaprofen. Pharmacological action: fluorescent dye Synonym: s-flopa (26 Jun 1999) |