| insulin receptor substrate-1 protein | <chemical> Amino acid sequence given in first source; a 180 kD protein that contains multiple phosphorylated tyrosine residues after insulin stimulation; human and rat forms (hirs-1 and irs-1) are homologous Synonym: insulin receptor substrate-1-like protein, irs-1 protein, irs-1 gene product, hirs-1 protein, hirs-1 gene product, insulin receptor substrate 1, insulin receptor substrate-1 (05 Dec 1998) |
|---|---|
| insulin resistance | Many people with noninsulin-dependent diabetes produce enough insulin, but their bodies do not respond to the action of insulin. This may happen because the person is overweight and has too many fat cells, which do not respond well to insulin. Also, as people age, their body cells lose some of the ability to respond to insulin. Insulin resistance is also linked to high blood pressure and high levels of fat in the blood. Another kind of insulin resistance may happen in some people who take insulin injections. They may have to take very high doses of insulin every day (200 units or more) to bring their blood glucose (sugar) down to the normal range. (09 Oct 1997) |
| insulin shock | A severe condition that occurs when the level of blood glucose (sugar) drops quickly. The signs are shaking, sweating, dizziness, double vision, convulsions, and collapse. Insulin shock may occur when an insulin reaction is not treated quickly enough. See: hypoglycaemia. (09 Oct 1997) |
| insulin shock treatment | Formerly used treatment for serious mental disorders in which the patient was given insulin to induce a seizure; supplanted by electroshock therapy. (05 Mar 2000) |
| insulin-stimulating peptide | <chemical> 71-amino acid containing peptide; corresponds to residues 115-143 and 144-184 of bovine serum albumin with the exception of a tyrosine insertion between residues 155 and 156; consists of two chains with mw 5000 and 3400 for each chain Synonym: h-isp, insulin-stimulating protein (05 Dec 1998) |
| insulin unit | The activity contained in 1/22 mg of the international standard of zinc-insulin crystals. (05 Mar 2000) |
| insulin zinc suspension | A sterile buffered suspension with zinc chloride, containing 40 or 80 units per ml; the solid phase of the suspension consists of a mixture of 7 parts of crystalline insulin and 3 parts of amorphous insulin. Synonym: lente insulin. (05 Mar 2000) |
| extended insulin zinc suspension | A long-acting insulin suspension, obtained from beef, with an approximate time of onset of 7 hours and a duration of action of 36 hours. Synonym: crystalline insulin zinc suspension. (05 Mar 2000) |
| ultralente insulin | A form of zinc precipitated insulin in suspension in which the particle size is large, and thus release into the bloodstream after subcutaneous injection is slow; it can be mixed with other insulins having different particle sizes to achieve different durations of activity. Can be derived from porcine, bovine, or genetically engineered human type. (05 Mar 2000) |
| lente insulin | A sterile buffered suspension with zinc chloride, containing 40 or 80 units per ml; the solid phase of the suspension consists of a mixture of 7 parts of crystalline insulin and 3 parts of amorphous insulin. Synonym: lente insulin. (05 Mar 2000) |
| HIV long-terminal repeat | Regulatory sequences important for viral replication that are located on each end of the HIV genome. The ltr includes the HIV enhancer, promoter, and other sequences. Specific regions in the ltr include the negative regulatory element (nre), nf-kappa b binding sites , sp1 binding sites, tata box, and trans-acting responsive element (tar). The binding of both cellular and viral proteins to these regions regulates HIV transcription. (12 Dec 1998) |
| segment long spacing | <biochemistry> Abnormal packing pattern of collagen molecules formed if ATP is added to acidic collagen solutions, in which lateral aggregates of molecules are produced. Each aggregate is 300 nm long and the molecules are all in register. If segment long spacing aggregates are overlapped with a quarter stagger, the 67 nm banding pattern of normal fibrils is reconstituted. Acronym: SLS (18 Nov 1997) |
| insurance, long-term care | Health insurance to provide full or partial coverage for long-term home care services or for long-term nursing care provided in a residential facility such as a nursing home. (12 Dec 1998) |
| long | 1. Drawn out in a line, or in the direction of length; protracted; extended; as, a long line; opposed to short, and distinguished from broad or wide. 2. Drawn out or extended in time; continued through a considerable tine, or to a great length; as, a long series of events; a long debate; a long drama; a long history; a long book. 3. Slow in passing; causing weariness by length or duration; lingering; as, long hours of watching. 4. Occurring or coming after an extended interval; distant in time; far away. "The we may us reserve both fresh and strong Against the tournament, which is not long." (Spenser) 5. Extended to any specified measure; of a specified length; as, a span long; a yard long; a mile long, that is, extended to the measure of a mile, etc. 6. Far-reaching; extensive. " Long views." 7. Prolonged, or relatively more prolonged, in utterance; said of vowels and syllables. See Short, 13, and Guide to Pronunciation, 22. Long is used as a prefix in a large number of compound adjectives which are mostly of obvious meaning; as, long-armed, long-beaked, long-haired, long-horned, long-necked, long-sleeved, long-tailed, long- worded, etc. In the long run, in the whole course of things taken together; in the ultimate result; eventually. Long clam, to hold stock for a rise in price, or to have a contract under which one can demand stock on or before a certain day at a stipulated price; opposed to short in such phrases as, to be short of stock, to sell short, etc. See Short. To have a long head, to have a farseeing or sagacious mind. Origin: AS. Long, lang; akin to OS, OFries, D, & G. Lang, Icel. Langr, Sw. Lang, Dan. Lang, Goth. Laggs, L.longus. Cf. Length, Ling a fish, Linger, Lunge, Purloin. 1. To a great extent in apace; as, a long drawn out line. 2. To a great extent in time; during a long time. "They that tarry long at the wine." (Prov. Xxiii. 30) "When the trumpet soundeth long." (Ex. Xix. 13) 3. at a point of duration far distant, either prior or posterior; as, not long before; not long after; long before the foundation of Rome; long after the Conquest. 4. Through the whole extent or duration. "The bird of dawning singeth all night long." (Shak) 5. Through an extent of time, more or less; only in question; as, how long will you be gone? Origin: AS. Lance. Source: Websters Dictionary (01 Mar 1998) |
| long abductor muscle of thumb | <anatomy> Origin, interosseous membrane and posterior surfaces of radius and ulna; insertion, lateral side of base of first metacarpal bone; action, abducts and assists in extending thumb; nerve supply, radial. Synonym: musculus abductor pollicis longus, long abductor muscle of thumb, musculus extensor ossis metacarpi pollicis. (05 Mar 2000) |