| Hodgkin's lymphoma | <haematology, oncology> A human malgnant disorder of lymph tissue (lymphoma) that appears to originate in a particular lymph node and later spreads to the spleen, liver and bone marrow. It occurs mostly in individuals between the ages of 15 and 35. It is characterised by progressive, painless enlargement of the lymph nodes, spleen and general lymph tissue. Giant cells, the Reed Sternberg cells, with mirror image nuclei are diagnostic. Immunological depletion, caused perhaps by the excessive growth of neoplastic histiocytes, occurs. Four types of the disease are recognised depending on the relative predominance of various neoplastic derivatives of the lymphoid series. Pyrexia is often a feature of the disease. Death often results from generalised immunological inability to respond to infections. If detected early, it has a high remission rate. Staging: Ann Arbor classification; each stage is further classified as:, A no symptoms, B fever, sweats, weight loss. Stage I - involvement of a single lymph-node region or extralymphatic site. Stage II - two or more sites of involvement on the same side of the diaphragm. Stage III - disease involvement on both sides of the diaphragm. Stage IV - disseminated disease of extralymphatic organs, with or without lymph-node involvement. Indicence: approximately 1,500 new cases per year in the UK. (30 Mar 2000) |
|---|---|
| small bowel lymphoma | <radiology> Patterns:, infiltrative dilatation, nodular multiple filling defects, polypoid may cause intussiception from leading point associated with Burkitt lymphoma, endoexoenteric fistulae (12 Dec 1998) |
| small lymphocytic lymphoma | <tumour> Essentially the same disease as chronic lymphocytic leukaemia, except that lymphocytes are not increased in the peripheral blood; lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes. Synonym: small lymphocytic lymphoma. (05 Mar 2000) |
| nodular histiocytic lymphoma | <tumour> A B-cell lymphoma with nodular or diffuse lymph node or bone marrow involvement by large lymphoid cells. Synonym: follicular predominantly small cleaved cell lymphoma, nodular histiocytic lymphoma. (05 Mar 2000) |
| nodular lymphoma | <tumour> A malignant lymphoma arising from lymphoid follicular B-cells which may be small or large, growing in a nodular pattern. Synonym: follicular lymphoma, giant follicular lymphoblastoma. (05 Mar 2000) |
| non-Hodgkin's lymphoma | <oncology, tumour> A group of lymphomas which differ in important ways from Hodgkin's disease and are classified according to the microscopic appearance of the cancer cells. The disease is classified as either low grade (slowly growing), intermediate grade or high grade (rapidly growing) and may be treated in a variety of ways depending on the exact diagnosis. Previously called lymphosarcoma. (30 Sep 1997) |
| immunoblastic lymphoma | <tumour> A monomorphous proliferation of immunoblasts involving the lymph nodes; it may develop in some patients with angioimmunoblastic lymphadenopathy. (05 Mar 2000) |
| extra nodal lymphoma | <oncology, tumour> Literally outside the lymph nodes, but exhibiting the characteristics of lymph node cancer. A term used to describe the extent and site of disease. (27 Sep 1997) |
| Ki-1+ lymphoma | <tumour> A form of lymphoma characterised by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2). Synonym: Ki-1+ lymphoma. (05 Mar 2000) |
| follicular lymphoma | <tumour> A malignant lymphoma arising from lymphoid follicular B-cells which may be small or large, growing in a nodular pattern. Synonym: follicular lymphoma, giant follicular lymphoblastoma. (05 Mar 2000) |
| Lennert's lymphoma | <tumour> Malignant lymphoma with a high proportion of diffusely scattered epithelioid cells, tonsillar involvement, and an unpredictable course. Synonym: Lennert's lesion. (05 Mar 2000) |
| lymphoblastic lymphoma | <tumour> A diffuse lymphoma in children, with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei; many patients develop acute lymphoblastic leukaemia. (05 Mar 2000) |
| lymphocytic lymphoma | <oncology, tumour> A cancer of lymphatic tissues, the tumour cells are mostly abnormal lymphocytes. (13 Nov 1997) |
| lymphoma | <oncology, tumour> Malignant tumour of lymphoblasts derived from B lymphocytes. most commonly affects children in tropical Africa: both Epstein Barr virus and immunosuppression due to malarial infection are involved. (18 Nov 1997) |
| lymphoma, aids-related | B-cell lymphoid tumours that occur in association with aids. Patients often present with an advanced stage of disease and highly malignant subtypes including burkitt lymphoma, immunoblastic large-cell lymphoma, small non-cleaved-cell lymphoma and diffuse large-cell lymphoma. The tumours are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in aids is a complex result of ebv infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (12 Dec 1998) |