| malignant lymphoma | <tumour> A general term for ordinarily malignant neoplasms of lymphoid and reticuloendothelial tissues which present as apparently circumscribed solid tumours composed of cells that appear primitive or resemble lymphocytes, plasma cells, or histiocytes. Lymphomas appear most frequently in lymph nodes, spleen, or other normal sites of lymphoreticular cells; when disseminated, Lymphoma's, especially of the lymphocytic type, may invade the peripheral blood and manifest as leukaemia. Lymphomas are classified by cell type, degrees of differentiation, and nodular or diffuse pattern; Hodgkin's disease and Burkitt's lymphoma are special forms. (05 Mar 2000) |
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| Mediterranean lymphoma | A spectrum of conditions ranging from a benign plasma cell hyperplasia to a highly malignant lymphoma of the small intestine. (12 Dec 1998) |
| well-differentiated lymphocytic lymphoma | <tumour> Essentially the same disease as chronic lymphocytic leukaemia, except that lymphocytes are not increased in the peripheral blood; lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes. Synonym: small lymphocytic lymphoma. (05 Mar 2000) |
| poorly differentiated lymphocytic lymphoma | <tumour> A B-cell lymphoma with nodular or diffuse lymph node or bone marrow involvement by large lymphoid cells. Synonym: follicular predominantly small cleaved cell lymphoma, nodular histiocytic lymphoma. (05 Mar 2000) |
| histiocytic lymphoma | <tumour> A malignant tumour of reticular tissue composed predominantly of neoplastic histiocytes. See: large cell lymphoma. (05 Mar 2000) |
| Hodgkin's lymphoma | <haematology, oncology> A human malgnant disorder of lymph tissue (lymphoma) that appears to originate in a particular lymph node and later spreads to the spleen, liver and bone marrow. It occurs mostly in individuals between the ages of 15 and 35. It is characterised by progressive, painless enlargement of the lymph nodes, spleen and general lymph tissue. Giant cells, the Reed Sternberg cells, with mirror image nuclei are diagnostic. Immunological depletion, caused perhaps by the excessive growth of neoplastic histiocytes, occurs. Four types of the disease are recognised depending on the relative predominance of various neoplastic derivatives of the lymphoid series. Pyrexia is often a feature of the disease. Death often results from generalised immunological inability to respond to infections. If detected early, it has a high remission rate. Staging: Ann Arbor classification; each stage is further classified as:, A no symptoms, B fever, sweats, weight loss. Stage I - involvement of a single lymph-node region or extralymphatic site. Stage II - two or more sites of involvement on the same side of the diaphragm. Stage III - disease involvement on both sides of the diaphragm. Stage IV - disseminated disease of extralymphatic organs, with or without lymph-node involvement. Indicence: approximately 1,500 new cases per year in the UK. (30 Mar 2000) |
| small bowel lymphoma | <radiology> Patterns:, infiltrative dilatation, nodular multiple filling defects, polypoid may cause intussiception from leading point associated with Burkitt lymphoma, endoexoenteric fistulae (12 Dec 1998) |
| small lymphocytic lymphoma | <tumour> Essentially the same disease as chronic lymphocytic leukaemia, except that lymphocytes are not increased in the peripheral blood; lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes. Synonym: small lymphocytic lymphoma. (05 Mar 2000) |
| nodular histiocytic lymphoma | <tumour> A B-cell lymphoma with nodular or diffuse lymph node or bone marrow involvement by large lymphoid cells. Synonym: follicular predominantly small cleaved cell lymphoma, nodular histiocytic lymphoma. (05 Mar 2000) |
| nodular lymphoma | <tumour> A malignant lymphoma arising from lymphoid follicular B-cells which may be small or large, growing in a nodular pattern. Synonym: follicular lymphoma, giant follicular lymphoblastoma. (05 Mar 2000) |
| non-Hodgkin's lymphoma | <oncology, tumour> A group of lymphomas which differ in important ways from Hodgkin's disease and are classified according to the microscopic appearance of the cancer cells. The disease is classified as either low grade (slowly growing), intermediate grade or high grade (rapidly growing) and may be treated in a variety of ways depending on the exact diagnosis. Previously called lymphosarcoma. (30 Sep 1997) |
| immunoblastic lymphoma | <tumour> A monomorphous proliferation of immunoblasts involving the lymph nodes; it may develop in some patients with angioimmunoblastic lymphadenopathy. (05 Mar 2000) |
| extra nodal lymphoma | <oncology, tumour> Literally outside the lymph nodes, but exhibiting the characteristics of lymph node cancer. A term used to describe the extent and site of disease. (27 Sep 1997) |
| Ki-1+ lymphoma | <tumour> A form of lymphoma characterised by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2). Synonym: Ki-1+ lymphoma. (05 Mar 2000) |
| follicular lymphoma | <tumour> A malignant lymphoma arising from lymphoid follicular B-cells which may be small or large, growing in a nodular pattern. Synonym: follicular lymphoma, giant follicular lymphoblastoma. (05 Mar 2000) |