| granulation tissue | Highly vascularised tissue that replaces the initial fibrin clot in a wound. Vascularisation is by ingrowth of capillary endothelium from the surrounding vasculature. The tissue is also rich in fibroblasts (that will eventually produce the fibrous tissue) and leucocytes. (18 Nov 1997) |
|---|---|
| granulationes | Plural of granulatio. (05 Mar 2000) |
| granulationes arachnoideales | Tufted prolongations of pia-arachnoid, composed of numerous arachnoid villi that penetrate dural venous sinuses and effect transfer of cerebrospinal fluid to the venous system. at advanced age these are more numerous and tend to calcify. Synonym: granulationes arachnoideales, arachnoidal granulations, pacchionian bodies, pacchionian corpuscles, pacchionian glands, pacchionian granulations. (05 Mar 2000) |
| granule | <pharmacology> A small quantity of a solid substance, smaller than a grain. Origin: L. Granulum (18 Nov 1997) |
| granule cell | Type of neuron found in the cerebellum. (18 Nov 1997) |
| granule cell of connective tissue | <cell biology, immunology> Resident cell of connective tissue that contains many granules rich in histamine and heparan sulphate. Release of histamine from mast cells is responsible for the immediate reddening of the skin in a weal and flare response. Very similar to basophils and possibly derived from the same stem cells. Two types of mast cells are now recognised, those from connective tissue and a distinct set of mucosal mast cells, the activities of the latter are T-cell dependent. (05 Jan 1998) |
| granule cells | Small nerve cell bodies in the external and internal granular layers of the cerebral cortex, small nerve cell bodies in the granular layer of the cerebellar cortex. (05 Mar 2000) |
| granuliform | <chemical> Having a granular structure; granular; as, granuliform limestone. Origin: Granule. Source: Websters Dictionary (01 Mar 1998) |
| granulite | <geology> A whitish, granular rock, consisting of feldspar and quartz intimately mixed; sometimes called whitestone, and leptynite. Origin: From Granule. Source: Websters Dictionary (01 Mar 1998) |
| granulo- | Granular, granules. Origin: L. Granulum, a small grain. (05 Mar 2000) |
| granuloblast | Rarely used term for an immature haematopoietic cell capable of giving rise to granulocytes. Origin: Granulo-+ G. Blastos, germ (05 Mar 2000) |
| granuloblastosis | A leukaemic form of leukosis in the chicken characterised by an increase of immature, granular blood cells in the circulating blood and frequently infiltration of the parenchymatous organs. (05 Mar 2000) |
| granulocyte | <haematology> Leucocyte with conspicuous cytoplasmic granules. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils (using a Romanovsky type stain), some invertebrate blood cells are also referred to, not very helpfully, as granulocytes. (12 Dec 1998) |
| granulocyte-colony-stimulating factor | <growth factor, haematology, oncology> A glycoprotein of 25 kD containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukaemic myeloid cell lines. A protein that stimulates the growth and maturation of granulocytes. It is used to promote the recovery of the white cells following chemotherapy. See: colony-stimulating factor. Acronym: G-CSF (12 Dec 1998) |
| granulocyte-macrophage colony-stimulating factor | <growth factor, haematology, oncology> An acidic glycoprotein of mw 23 kD with internal disulfide bonds. It is produced in response to a number of inflammatory mediators by mesenchymal cells present in the haemopoietic environment and at peripheral sites of inflammation. It stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from foetal liver progenitor cells. It also has some functional activities in mature granulocytes and macrophages. It is used to promote the recovery of the white blood cells following chemotherapy. Chemical name: Colony-stimulating factor 2 See: colony-stimulating factor. Acronym: GM-CSF (12 Dec 1998) |