| giant drusen | An obsolete term for a glial hamartoma of the optic nerve head or the peripapillary retina, seen in tuberous sclerosis. (05 Mar 2000) |
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| giant follicular lymphoblastoma | <tumour> A malignant lymphoma arising from lymphoid follicular B-cells which may be small or large, growing in a nodular pattern. Synonym: follicular lymphoma, giant follicular lymphoblastoma. (05 Mar 2000) |
| giant follicular thyroiditis | A variant of Hashimoto's thyroiditis in which lymphocytic infiltrate in thyroid has formed into giant follicles. (05 Mar 2000) |
| giant hairy nevus | <dermatology> These large pigmented (often hairy) congenital nevi are important because of their increased risk (10 to 15%) of conversion into malignant melanoma. A biopsy can confirm if cells have turned malignant. Any change in a pre-existing nevus should prompt a physician evaluation. (17 Dec 1997) |
| giant hives | A vascular reaction involving the deep dermis or subcutaneous or submucal tissues, representing localised oedema caused by dilatation and increased permeability of the capillaries and characterised by development of giant wheals. (18 Nov 1997) |
| giant lymph node hyperplasia | Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterised by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IgA. (12 Dec 1998) |
| giant melanosome | A large spherical melanosome (1 to 6 u in diameter) formed in the cytoplasm of melanocytes in cafe-au-lait spots and other melanocytic disorders. Synonym: macromelanosome. (05 Mar 2000) |
| giant osteoid osteoma | A benign, painful, tumour of bone characterised by the formation of osteoid tissue, primitive bone and calcified tissue. It occurs frequently in the spine of young persons. (12 Dec 1998) |
| giant pigmented nevus | These large pigmented (often hairy) congenital nevi are important because of their increased risk (10 to 15%) of conversion into malignant melanoma. A biopsy can confirm if cells have turned malignant. Any change in a pre-existing nevus should prompt a physician evaluation. (27 Sep 1997) |
| giant urticaria | A vascular reaction involving the deep dermis or subcutaneous or submucal tissues, representing localised oedema caused by dilatation and increased permeability of the capillaries and characterised by development of giant wheals. (18 Nov 1997) |
| reparative giant cell granuloma | <dermatology, oncology> A non-neoplastic lesion characterised by a proliferation of granulation tissue containing numerous multinucleated giant cells. It occurs on the gingiva and alveolar mucosa (occasionally on other soft tissues) where it presents as a soft red-blue haemorrhagic nodular swelling. It also occurs within the mandible or maxilla as a unilocular or multilocular radiolucency. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis), central refers to the jaw. Microscopically similar lesions occur in the tubular bones of the hands and feet, are considered neoplastic, and may have a malignant course. Identical bony lesions may be seen in hyperparathyroidism and cherubism. See: giant cell tumour of bone. Synonym: giant cell epulis. (05 Mar 2000) |
| congenital giant pigmented nevus | These large pigmented (often hairy) congenital nevi are important because of their increased risk (10 to 15%) of conversion into malignant melanoma. A biopsy can confirm if cells have turned malignant. Any change in a pre-existing nevus should prompt a physician evaluation. (27 Sep 1997) |
| squid giant axon | <physiology> Large axons, up to 1mm in diameter, that innervate the mantle of the squid. Because of their large size, many of the pioneering investigations of the mechanisms underlying resting and action potentials in excitable cells were done on these fibres. (10 Mar 1998) |
| subependymal giant cell astrocytoma | <tumour> A rare astrocytoma, frequently located in the wall of the lateral ventricle, comprised of large glial cells with abundant eosinophilic cytoplasm and intermixed elongated astrocytes, associated with tuberous sclerosis. (05 Mar 2000) |
| interstitial giant cell pneumonia | A rare complication of measles, with the postmortem finding of multinucleated giant cells lining alveoli. Synonym: Hecht's pneumonia, interstitial giant cell pneumonia. (05 Mar 2000) |