| genes, reporter | Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest. (12 Dec 1998) |
|---|---|
| genes, retinoblastoma | Tumour suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kD to 115 kD. One copy of the wild-type rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma. (12 Dec 1998) |
| genes, rev | DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). Rev is short for regulator of virion. (12 Dec 1998) |
| genes, src | Retrovirus-associated DNA sequences (src) originally isolated from the rous sarcoma virus (rsv). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20. (12 Dec 1998) |
| genes, structural | Genes that code for proteins required for the enzymatic and structural functions of cells. They include developmental and differentiated genes. (12 Dec 1998) |
| genes, structural, bacterial | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of bacterial cells. (12 Dec 1998) |
| genes, structural, fungal | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of fungal cells. (12 Dec 1998) |
| genes, structural, helminth | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of helminthic cells. (12 Dec 1998) |
| genes, structural, insect | DNA sequences that code for RNA and for proteins required for the enzymatic and structural function of insect cells. (12 Dec 1998) |
| genes, structural, neoplasm | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of neoplastic cells. (12 Dec 1998) |
| genes, structural, plant | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of plant cells. (12 Dec 1998) |
| genes, structural, protozoan | DNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of protozoan cells. (12 Dec 1998) |
| genes, structural, viral | DNA or RNA sequences that code for RNA and for the proteins required for the enzymatic and structural function of viral cells. (12 Dec 1998) |
| genes, suppressor | Genes that inhibit expression of a previous mutation. They allow the wild-type phenotype to be wholly or partially restored. (12 Dec 1998) |
| genes, suppressor, tumour | Genes that inhibit expression of the tumourigenic phenotype. They are normally involved in holding cellular growth in check. When tumour suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (12 Dec 1998) |