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formularies, hospital Formularies concerned with pharmaceuticals prescribed in hospitals.
(12 Dec 1998)
formulary A collection of formulas for the compounding of medicinal preparations.
See: National Formulary, Pharmacopeia.
(05 Mar 2000)
formulation <pharmacology> The mixture or prescribed recipe for packaging a protein pharmaceutical, the process of developing such a formulation.
(06 Mar 1998)
formycin B <drug> A drug used to get rid of intestinal parasites, it works by inhibiting the worm's ability to conduct nucleic acid synthesis.
(06 Mar 1998)
formycins <chemical> Pyrazolopyrimidine ribonucleosides isolated from nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.
Pharmacological action: antibiotics, antineoplastic.
(12 Dec 1998)
formyl <chemistry> A univalent radical, H.C:O, regarded as the essential residue of formic acid and aldehyde.
Formerly, the radical methyl, CH3.
Origin: Formic + -yl.
Source: Websters Dictionary
(01 Mar 1998)
formyl peptide <biochemistry> Informal term for small peptides with a formylated N terminal methionine and usually a hydrophobic amino acid at the carboxy terminal end (fMetLeuPhe is the most commonly used).
These peptides stimulate the motor and secretory activities of leucocytes, particularly neutrophils and monocytes, that have a specific receptor (about 60 kD) of high affinity (Kd approximately 10exp 8M).
Leucocytes show chemotaxis towards formyl peptides but the term chemotactic peptides understates the range of activities the molecules will trigger. Thought to be synthetic analogues of bacterial signal sequences though this is unproven. The leucocytes of many animals (e.g. Pig, cow, chicken) do not respond.
(18 Nov 1997)
formyl sterol oxidase <enzyme> Converts sterol 4-aldehyde to a carboxylic acid in presence of NADH or NADPH
Registry number: EC 1.2.1.-
(26 Jun 1999)
formyl-coenzyme A transferase <enzyme> From oxalbacter formigenes; has been sequenced; genbank u82167
Registry number: EC 2.8.3.-
Synonym: formyl-CoA transferase, frc gene product
(26 Jun 1999)
formyl-methenyl-methylenetetrahydrofolate synthetase <chemical> Trifunctional enzyme which contains EC 6.3.4.3, formyltetrahydrofolate synthetase, plus EC 3.5.4.9, methenyltetrahydrofolate cyclohydrolase, and EC 1.5.1.5, methylenetetrahydrofolate dehydrogenase as a complex in sheep liver
Chemical name: synthetase, formyl-methenyl-methylenetetrahydrofolate
Synonym: c1-thf synthase, c1-tetrahydrofolate synthase, formyl-methenyl-methylenetetrahydrofolate synthetase (combined), c-1-tetrahydrofolate synthetase, nadp-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase
(26 Jun 1999)
formylase <enzyme> Isolated from methylophilus methylotrophus; genbank x99632
Registry number: EC 3.5.1.49
Synonym: fmda gene product
(26 Jun 1999)
formylglutamate amidohydrolase <enzyme> From pseudomonas putida; degrades formylglutamate to glutamate and formate
Registry number: EC 3.5.1.-
Synonym: n-formyl-l-glutamate amidohydrolase
(26 Jun 1999)
formylmethanofuran dehydrogenase <enzyme> Catalyses the oxidation of formylmethanofuran to co2 and methanofuran with methyl viologen as artificial electron acceptor; from methanogenic bacteria
Registry number: EC 1.2.99.5
Synonym: fmf dehydrogenase, fmdabc gene product
(26 Jun 1999)
formylmethanofuran-tetrahydromethanopterin formyltransferase <enzyme> From methanobacterium thermoautotrophicum; role in methanogenesis from co2
Registry number: EC 2.1.2.-
Synonym: fmf-tmp formyltransferase
(26 Jun 1999)
formylmethionine Methionine acylated on the NH2 group by a formyl (-CHO) group. This is the starting amino acid residue for virtually all bacterial polypeptides.
See: initiating codon.
Synonym: N-formylmethionine.
(05 Mar 2000)
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