| Lo dose | <pharmacology> The limes nul dose of diphtheria toxin, i.e., the largest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, yields no recognizable reaction in the average of a series; actually, the Lod. Is usually recorded as the one that causes a barely perceptible local oedema at the site of inoculation. (05 Mar 2000) |
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| Lr dose | The limes reacting dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin and injected intracutaneously in the shaved skin of a susceptible guinea pig, yields a minimal, positive reaction and inflammation localised to the region of the injection; the Lrd. Closely approximates the Lod., as would be expected, inasmuch as a slight excess of unneutralised toxin results in a reaction. (05 Mar 2000) |