| MIC | maternal and infant care; medical intensive care; Medical Interfraternity Conference; microscopy; mi... |
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| OSI | open systems interconnection [reference model] |
| PBPK | physiologically based pharmacokinetic [model] |
| PDM | point distribution model |
| PRECEDE | predisposing, reinforcing, and enabling causes in educational diagnosis and evaluation [model] |
| Koshland-Nemethy-Filmer model | <biochemistry, chemistry> A model to explain the allosteric form of cooperativity; in this model, in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits. Synonym: Adair-Koshland-Nemethy-Filmer model, induced fit model. (05 Mar 2000) |
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| fluid bilayer model | Generally accepted model for membranes in cells. In its original form, the model held that proteins floated in a sea of phospholipids arranged as a bilayer with a central hydrophobic domain. Although it is now recognised that some proteins are restrained by interactions with cytoskeletal elements and that the phospholipid annulus around a protein may contain only specific types of lipid, the model is still considered broadly correct. (18 Nov 1997) |
| fluid mosaic model | A model used to conceptualise cell membranes, in it, the membranesare described as a structually and functionally asymmetric lipidbilayer studded with embedded proteins that aid in cross-membrane transport. (09 Oct 1997) |
| lock-and-key model | A model used to suggest the mode of operation of an enzyme in which the substrate fits into the active site of the protein like a key into a lock. (05 Mar 2000) |
| logistic model | A statistical model; in epidemiology, a model of risk as a function of exposure to a risk factor. (05 Mar 2000) |
| activated clotting time | The most common test used for coagulation time in cardiovascular surgery. (05 Mar 2000) |
| activated partial thromboplastin time | The time needed for plasma to form a fibrin clot following the addition of calcium and a phospholipid reagent; used to evaluate the intrinsic clotting system. (05 Mar 2000) |
| A-H conduction time | Forward conduction of the cardiac impulse from atria to ventricles via the A-V node or any bypass tract, represented in the electrocardiogram by the P-R interval. P-H conduction time is from the onset of the P wave to the first high frequency component of the His bundle electrogram (normally 119 ± 38 msec); A-H conduction time is from the onset of the first high frequency component of the atrial electrogram to the first high frequency component of the His bundle electrogram (normally 92 ± 38 msec); P-A conduction time is from the onset of the P wave to the onset of the atrial electrogram (normally 27 ± 18 msec). (05 Mar 2000) |
| association time | Time elasping between a stimulus and the verbalised response to it. (05 Mar 2000) |
| biologic time | The concept that our appreciation of time varies with age and is governed by the neural organization of the individual; it obeys a logarithmic rather than an arithmetic law. (05 Mar 2000) |
| bleeding time | <haematology> A test which measures the time it takes for small blood vessels to close off and bleeding to stop. Abnormal results can be seen in those with congenital or acquired platelet function disorders or thrombocytopenia. (27 Sep 1997) |
| blood circulation time | Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points. (12 Dec 1998) |
| P-A conduction time | See: atrioventricular conduction. (05 Mar 2000) |
| generation time | <cell biology> Time taken for a cell population to double in numbers and thus equivalent to the average length of the cell cycle. (18 Nov 1997) |
| reaction time | The time from the onset of a stimulus until the organism responds. (12 Dec 1998) |