| coagulation c. |
the series of steps beginning with activation of the intrinsic or extrinsic pathways of coagulation, or of one of the related alternative pathways, and proceeding through the common pathway of coagulation to the formation of the fibrin clot; each step involves zymogen activation, the activated zymogen catalyzing activation of the following step.
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| coagulation f. IX (human) |
a purified, sterile, dried concentrate of factor IX derived from pooled human plasma; used in the prophylaxis and treatment of bleeding in patients with hemophilia B, administered intravenously. Cf. coagulation f. IX (recombinant) and factor IX complex.
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| coagulation f. IX (recombinant) |
a sterile, dried concentrate of factor IX prepared by recombinant means; used in the prophylaxis and treatment of bleeding in patients with hemophilia B, administered intravenously. Cf. coagulation f. IX (human) and factor IX complex.
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| coagulation f.’s |
substances in the blood that are essential to the clotting process and hence, to the maintenance of normal hemostasis. They are designated by Roman numerals, to which the notation “a” is added to indicate the activated state. Platelet factors (q.v.) also play a role in coagulation.
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| coagulation n. |
necrosis in which tissue becomes a dry, opaque, eosinophilic mass containing the outlines of anucleated cells, resulting from the denaturation of proteins following hypoxic injury, such as that caused by ischemia in infarction. Called also avascular n. and ischemic n.
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