| lethal dose 50 | <pharmacology> The amount, or dosage, of a toxin necessary to kill 50% of the experimental subjects. (16 Mar 1998) |
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| Lf dose | The limes flocculation dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin, yields the most rapid flocculation in the Ramon test (in vitro); in general, the Lf dose is slightly less than the Lr dose. (05 Mar 2000) |
| loading dose | <pharmacology> A quantity higher than the average or maintenance dose, used at the initiation of therapy to rapidly establish a desired level of the drug (18 Nov 1997) |
| Lo dose | <pharmacology> The limes nul dose of diphtheria toxin, i.e., the largest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, yields no recognizable reaction in the average of a series; actually, the Lod. Is usually recorded as the one that causes a barely perceptible local oedema at the site of inoculation. (05 Mar 2000) |
| Lr dose | The limes reacting dose of diphtheria toxin, i.e., the smallest amount of toxin that, when mixed with one unit of antitoxin and injected intracutaneously in the shaved skin of a susceptible guinea pig, yields a minimal, positive reaction and inflammation localised to the region of the injection; the Lrd. Closely approximates the Lod., as would be expected, inasmuch as a slight excess of unneutralised toxin results in a reaction. (05 Mar 2000) |