| anthramycin | <chemical> 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-2-propenamide. A broad-spectrum spectrum antineoplastic antibiotic isolated from streptomyces refuineus var. Thermotolerans. It has low toxicity, some activity against trichomonas and endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA. Pharmacological action: antibiotics, antineoplastic. Chemical name: 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))- (12 Dec 1998) |
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| anthranilate monooxygenase | <enzyme> Catalyses the hydroxylation of anthranilate to hydroxyanthranilate in the presence of tetrahydropteridine and molecular oxygen; anthranilate hydroxylase is a synonym for this and EC 1.14.12.1 and EC 1.14.13.35 (formerly EC 1.14.12.2) Registry number: EC 1.14.16.3 Synonym: anthranilate 3-hydroxylase, anthranilate 3-monooxygenase (26 Jun 1999) |
| anthranilate phosphoribosyltransferase | <enzyme> An enzyme that catalyses the formation of n-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in e. Coli. It exists in a complex with anthranilate synthase in bacteria. Chemical name: N-(5-Phospho-D-ribosyl)-anthranilate:pyrophosphate phospho-alpha-D-ribosyltransferase Registry number: EC 2.4.2.18 (12 Dec 1998) |
| anthranilate synthase | <enzyme> An enzyme that catalyses the formation of anthranilate (o-aminobenzoate) and pyruvic acid from chorismate and glutamine. Anthranilate is the biosynthetic precurser of tryptophan and numerous secondary metabolites, including inducible plant defense compounds. Chemical name: Chorismate pyruvate-lyase (amino-accepting) Registry number: EC 4.1.3.27 (12 Dec 1998) |
| anthranilic acid | One of the products of tryptophan catabolism. Synonym: o-aminobenzoic acid. (05 Mar 2000) |
| anthranilic acids | Benzoic acids which are substituted with an amino group in the c-2 position. (12 Dec 1998) |
| anthraniloyl | The acyl radical of anthranilic acid. (05 Mar 2000) |
| anthraonite | <chemical> A coal-black marble, usually emitting a fetid smell when rubbed. Synonym: stinkstone and swinestone. See: Anthracite. Source: Websters Dictionary (01 Mar 1998) |
| anthrapurpurin | C14H8O5; 1,2,7-Trihydroxyanthraquinone;a purple dye used in histology as a reagent for calcium, although the specificity has been questioned. (05 Mar 2000) |
| anthraquinone | <chemistry> A hydrocarbon, C6H4.C2O2.C6H4, subliming in shining yellow needles. It is obtained by oxidation of anthracene. Origin: Anthracene + quinone. Source: Websters Dictionary (01 Mar 1998) |
| anthraquinones | An anthracene ring which contains two ketone moieties in any position. Can be substituted in any position except on the ketone groups. (12 Dec 1998) |
| anthrax | <disease, microbiology> An infectious bacterial zoonotic disease usually acquired by ingestion of Bacillus anthracis or its spores from infected pastures by herbivores or indirectly from infected carcasses by carnivores. It is transmitted to humans usually by contact with infected animals or their discharges (agricultural anthrax) or with contaminated animal products (industrial anthrax). Anthrax is classified by primary routes of inoculation as: cutaneous, gastrointestinal and inhalational. Synonym: charbon, milzbrand and splenic fever. (18 Nov 1997) |
| anthrax immunization | A series of six shots over six months and booster shots annually, the anthrax vaccine now in use in the USA was first developed in the 1950s and approved by the Food and Drug Administration for general use in 1970. It is produced by the Michigan Biologic Products Institute of Michigan's Department of Health and is given routinely to veterinarians and others working with livestock. In December, 1997 it was announced that all US military would receive the vaccine, as do the military in the UK and Russia, the reason being concern that anthrax might be used in biologic warfare. (12 Dec 1998) |
| anthrax pneumonia | A form of anthrax acquired by inhalation of dust containing Bacillus anthracis; there is an initial chill followed by pain in the back and legs, rapid respiration, dyspnea, cough, fever, rapid pulse, and extreme cardiovascular collapse. Synonym: anthrax pneumonia, ragpicker's disease, ragsorter's disease, rag-sorter's disease, wool-sorter's pneumonia, woolsorter's disease, wool-sorter's disease. (05 Mar 2000) |
| anthrax septicaemia | The presence of Bacillus anthracis in the circulating blood, usually resulting from previously developed anthrax of the skin or lungs. Synonym: anthrax septicaemia. (05 Mar 2000) |