| alpha-aminoglutaric acid | <amino acid> One of the 20 _ amino acids commonly found in proteins. Plays a central role in amino acid metabolism, acting as precursor of glutamine, proline and arginine. Also acts as amino group donor in synthesis by transamination of alanine from pyruvate and aspartic acid from oxaloacetate. Glutamate is also a neurotransmitter, the product of its decarboxylation is the inhibitory neurotransmitter amino butyrate (GABA). (18 Nov 1997) |
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| alpha-aminoisobutyric acid | 2-amino-2-methylpropionic acid;a synthetic amino acid useful in the study of amino acid transport across cell membranes and in the study of cytokine effects; it is not metabolised by the cell. (05 Mar 2000) |
| alpha-aminosuccinic acid | <amino acid> One of the twenty naturally occurring amino acids. Has the following chemical characteristics: pKa1 pKa2 pKa3 pI Water Solubility (30deg C)2.09-3.86 9.82 2.97 0.6 (09 Oct 1997) |
| alpha-amylase | <enzyme> An enzyme that catalyses the endohydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides and oligosaccharides containing 3 or more 1,4-alpha-linked d-glucose units. Pharmacological action: anti-inflammatory agents. Chemical name: 1,4-alpha-D-Glucan glucanohydrolase Registry number: EC 3.2.1.1 (12 Dec 1998) |
| alpha-antitrypsin deficiency | <enzyme> A specific enzyme (alpha 1 antitrypsinase) that when absent genetically can result in panacinar emphysema (lung disease) and liver disease. There is no specific treatment for this condition other than supportive care for the liver and lung complications. Medications such as alpha-1proteinase inhibitor is given regularly to these patients. Incidence: approximately 1 in 10,000. (02 Jan 1998) |
| alpha-blocker | An agent that competitively blocks alpha-adrenergic receptors; used in the treatment of hypertension. Synonym: alpha-blocker. (05 Mar 2000) |
| alpha-chloralose | A conjugate of chloral and glucose used as an anaesthetic in laboratory animals; it does not depress cardiovascular reflexes as much as most other anaesthetic agents. (05 Mar 2000) |
| alpha-chlorohydrin | <chemical> 3-chloro-1,2-propanediol. A chlorinated propanediol compound that has shown anti-fertility activity in males and has been used as a chemosterilant in rodents. Pharmacological action: chemosterilants, contraceptive agents, male. Chemical name: 1,2-Propanediol, 3-chloro- (12 Dec 1998) |
| alpha-chymotrypsin-induced glaucoma | Transient secondary glaucoma following the use of alpha-chymotrypsin in cataract extraction. (05 Mar 2000) |
| alpha-cortol | 5b-Pregnane-3a,11b,17,20a,21-pentaol; the 5b enantiomer of alpha-allocortol;a reduction product of cortisone, present in the urine, differing from cortisone in that the three keto groups are reduced to hydroxyls. (05 Mar 2000) |
| alpha-cortolone | 3a,17a,20a,21-Tetrahydroxy-5b-pregnane-11-one;the 5b enantiomer of alpha-allocortolone; a reduction product of cortisone, present in the urine, differing from cortisone in that two of the keto groups (at positions 3 and 20) are reduced to hydroxyls. (05 Mar 2000) |
| alpha-d-galactosidase | <enzyme> An enzyme catalyzing the hydrolysis of alpha-d-galactosides to release free d-galactose. A deficiency of type A alpha-d-galactosidase is associated with Fabry's disease. Synonym: melibiase. (05 Mar 2000) |
| alpha-d-glucosidase | A glucohydrolase removing terminal nonreducing 1,4-linked alpha-glucose residues by hydrolysis, yielding alpha-glucose; a deficiency of the lysosomal enzyme is associated with glycogen storage disease type II. There are at least five isozymes of maltase. Synonym: glucoinvertase. (05 Mar 2000) |
| alpha-D-mannose-beta-1,2-N-acetylglucosaminyltransferase | <enzyme> Absolute specificity for terminal branched mannosyl residues of glycolipids Registry number: EC 2.4.1.- Synonym: udpgnac-1,2-magtransferase (26 Jun 1999) |
| alpha-D-xylosidase | <enzyme> Highly specific for 4-nitrophenyl alpha-d-xylopyranoside and isoprimeverose; can also split off the alpha-d-xylopyranosyl residue on the non-reducing terminal of the backbone of certain oligoxyloglucans Registry number: EC 3.2.1.- Synonym: alpha-d-xylosidase I, alpha-d-xylosidase II (26 Jun 1999) |
| N-acetylgalactosamine-mucin alpha-N-1,3-N-acetylgalactosaminyltransferase | <enzyme> Forms sia-alpha2-6(gal-nac-alpha1-3)galnac-mucin Registry number: EC 2.4.1.- Synonym: mucin-acetylgalactosaminyltransferase, mucin-gal-nac-transferase (26 Jun 1999) |
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| N-acetyllactosamine alpha-D-galactosyltransferase | <enzyme> Transfers galactose to asialo-alpha 1-acid glycoprotein and n-acetyllactosamine Registry number: EC 2.4.1.124 Synonym: udp-gal-n-acetyllactosaminide alpha-1,3-galactosyltransferase, alpha-1-3-galactosyltransferase (26 Jun 1999) |
| N-acetyllactosaminide alpha-1,3-galactosyltransferase | <enzyme> Acts on beta-galactosyl-1,4-n-acetylglucosaminyl termini in asialo-alpha(1)-acid glycoprotein and n-acetyllactosamine, but not on 2'-fucosylated-n-acetyllactosamine Registry number: EC 2.4.1.151 Synonym: nac-lac-1,3-galtransferase, udp-n-acetyllactosaminide alpha-1,3-galactosyltransferase, udp-galactose-beta-d-galactosyl-alpha-1,3-galactosyltransferase, alpha1,3gt (26 Jun 1999) |
| N-alpha-acetylenkephalin carboxypeptidase | <enzyme> Removes sequentially 2 amino acids from c-terminal end of n-acetyl(met5)- or n-acetyl(leu5)-enkephalins; non-acetylated enkephalins less active; a metallocarboxypeptidase Registry number: EC 3.4.17.- Synonym: n-acetyltyrosine deacetylase (26 Jun 1999) |
| neolactotetraosylceramide alpha-2,3-sialyltransferase | <enzyme> Catalyses formation of lm1 and cmp from cmp-n-acetylneuraminate and neolactotetraosylceramide Registry number: EC 2.4.99.10 Synonym: cmp-n-acetylneuraminate-neolactotetraosylceramide alpha-2,3-sialyltransferase, cmp-neuac-nlcose4cer alpha2,3sialyltransferase, sat-3 enzyme (26 Jun 1999) |
| steroid 11-alpha-hydroxylase | <enzyme> Converts 11-deoxycortisol to 11-alpha cortisol (the 11-alpha isomer of hydrocortisone) Registry number: EC 1.14.99.- (26 Jun 1999) |
| steroid 14-alpha-hydroxylase | <enzyme> From induced vegetative cell cultures of mucor piriformis; hydroxylates progesterone to 14-alpha-hydroxyprogesterone in the presence of NADPH and oxygen Registry number: EC 1.14.13.- Synonym: progesterone 14-alpha-hydroxylase (26 Jun 1999) |
| steroid 17 alpha-monooxygenase | <enzyme> A steroid hydroxylase system found in the microsomal membrane of the steroid-hormone producing tissues. It catalyses the 17-hydroxylation of steroids, such as progesterone or pregnenolone in the presence of NADPH and molecular oxygen. This is an important step in the biosynthesis of steroid hormones. Chemical name: Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating) Registry number: EC 1.14.99.9 (12 Dec 1998) |
| steroid 7 alpha-hydroxylase | <enzyme> Testosterone and androstenedione incubated with microsomes from rat testes produced 7alpha-hydroxytestosterone and 7alpha-hydroxyandrostenedione Registry number: EC 1.14.99.- Synonym: testicular 7 alpha-hydroxylase, 7 alpha-hydroxylase, microsomal 7alpha-hydroxylase, andiostenedione 7 alpha-hydroxylase, sterol 7 alpha-hydroxylase, cytochrome p-450iia1, cytochrome p450iia1 (26 Jun 1999) |
| steroid 9 alpha monooxygenase | <enzyme> Consists of an electron transport chain of NADH-dependent flavoprotein reductase and 2 iron-sulfur proteins; from nocardia Registry number: EC 1.14.99.- Synonym: steroid 9 alpha-hydroxylase (26 Jun 1999) |
| steroid alpha-ketol oxidase | <enzyme> In conjunction with corticosteroid side-chain-isomerase (EC 5.3.1.21) converts desoxycorticosterone to a 20-oxo-21-oic acid (pregnenoic acid) Registry number: EC 1.2.1.- (26 Jun 1999) |
| N-nitrosopyrrolidine alpha-hydroxylase | <enzyme> A variety of cytochrome p-450 isoenzymes involved in rabbit liver microsomal activity Registry number: EC 1.14.13.- Synonym: npa-hydroxylase (26 Jun 1999) |
| sucrose alpha-d-glucohydrolase | <enzyme> An enzyme hydrolyzing sucrose and maltose; in a complex with isomaltase; hence, hydrolyzes both sucrose and isomaltose; found in the intestinal mucosa; a deficiency of this enzyme results in defective digestion of sucrose and linear a1,4-glucans. Synonym: sucrase. (05 Mar 2000) |
| d(-)-alpha-aminobenzylpenicillin | <drug> Penicillin derivative with broad spectrum activity, ampicillin resistance is often used as a marker for plasmid transfer in genetic engineering (for example pBR322 is ampicillin resistant). (13 Nov 1997) |
| deficiency, alpha-1 antitrypsin | An inherited disease with little or no production of an important protein, alpha-1 antitrypsin. The lack of this protein leads to damage of various organs, mainly the lung and liver. The disease may become apparent at a very early age or in adulthood, as shortness of breath or liver-related symptoms (jaundice, fatigue, fluid in the abdomen, mental changes, or gastrointestinal bleeding). There are several options for treatment of the lung disease, including replacement of the missing protein. Treatment of the liver disease is a well-timed liver transplant (12 Dec 1998) |