| topotecan | <drug, oncology> This alkaloid chemotherapy drug is a derivative of the drug camptothecin, which was originally isolated from a Chinese tree, Camptotheca acuminata but has also been found in the nothapodytes tree (Nothapodytes foetida).Topotecan is a DNA topoisomerase I inhibitor and is used to treat advanced ovarian cancer. (09 Oct 1997) |
|---|---|
| topothermesthesiometer | <instrument> A device for determining the temperature sense in different parts of the surface. Origin: topo-+ G. Therme, heat, + aisthesis, sensation, + metron, measure (05 Mar 2000) |
| topotype | <zoology> A specimen collected at the type locality. (09 Jan 1998) |
| topotypical population | <zoology> Population occurring at the type locality from which the type specimen was taken. (09 Jan 1998) |
| topping and back pressure turbine | Turbines which operate at exhaust pressure considerably higher than atmospheric (noncondensing turbines). These turbines are often multistage types with relatively high efficiency. (05 Dec 1998) |
| topping cycle | A cogeneration system in which electric power is produced first. The reject heat from power production is then used to produce useful process heat. (05 Dec 1998) |
| toppling gait | <neurology> A gait in which the steps are uncertain and hesitant, and the patient totters and sometimes falls; probably due to a balance disorder; may be seen in elderly patients after a stroke. (06 Mar 2000) |
| topsoil | The upper part of the soil profile that is relatively rich in humus, which is technically known as the A-horizon of the soil profile. (09 Oct 1997) |