| NUC | the branch of physics that studies the internal structure of atomic nuclei |
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| NUC | the protoplasm that constitutes the nucleus of a cell |
| NUC | any of several substances found in the nuclei of all living cells |
| NUC | a glycoside formed by partial hydrolysis of a nucleic acid |
| NUC | a phosphoric ester of a nucleoside |
| NUC | a part of the cell containing DNA and RNA and responsible for growth and reproduction |
| NUC | any histologically identifiable mass of neural cell bodies in the brain or spinal cord |
| NUC | a small group of indispensable persons or things |
| NUC | the positively charged dense center of an atom |
| NUC | (astronomy) the center of the head of a comet |