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nicotinic acetylcholine receptor Integral membrane protein of the postsynaptic membrane to which acetylcholine binds. The receptor contains an integral ion channel, as a result of binding of acetylcholine, ion channels in the subsynaptic membrane are opened. at the neuromuscular junction, the nicotinic acetylcholine receptor initiates muscle contraction. Currently the best characterised ion channel protein: made of a hetero pentamer of related subunits, although a homo pentamer is functional in insects. Structural studies show that the acetylcholine binding site and the ionic channel are part of the same macromolecular unit. The nAChR mediates rapid transduction events (1ms) whereas receptors activating G-protein coupled channels operate on slower time scales (millisecond to second range).
(18 Nov 1997)
nicotinic acid A precursor of NAD, that is a product of the oxidation of nicotine.
(18 Nov 1997)
nicotinic acid amide <biochemistry> Member of the water soluble B vitamin group, used in the production of fatty acids, steroids and cholesterol, deficiency is known as pellagra. Has cholesterol-lowering and vasodilating properties.
(27 Sep 1997)
nicotinic acid maculopathy Maculopathy observed in persons taking 3000 mg or more of nicotinic acid daily; normal vision returns after this medication is discontinued.
(05 Mar 2000)
nicotinic acids 2-, 3-, or 4-pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (niacin) is active as a vitamin.
(12 Dec 1998)
nicotinic agonists Drugs that bind to and activate nicotinic cholinergic receptors (receptors, nicotinic). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarising blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
(12 Dec 1998)
nicotinic alcohol <chemical> 3-pyridinemethanol. A direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened gangrene.
Pharmacological action: vasodilator agents.
Chemical name: 3-Pyridinemethanol
(12 Dec 1998)
nicotinic antagonists Drugs that bind to nicotinic cholinergic receptors (receptors, nicotinic) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
(12 Dec 1998)
nicotinic cholinergic receptor A class of receptors responsive to acetylcholine that also are activated by nicotine; ganglionic (including the adrenal medulla) and neuromuscular receptors. Two classes exist: nicotinic-neuronal and nicotinic-muscular.
(05 Mar 2000)
nicotinic receptors A class of cholinergic receptors on skeletal muscle cells that are linked to ion channels in the cell membrane.
(05 Mar 2000)
nicotinomimetic Mimicking the action of nicotine.
(05 Mar 2000)
nicotinyl alcohol <chemical> 3-pyridinemethanol. A direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened gangrene.
Pharmacological action: vasodilator agents.
Chemical name: 3-Pyridinemethanol
(12 Dec 1998)
nicotinyl tartrate 3-Pyridinemethanol tartrate;a relatively weak peripheral vasodilator related to nicotinic acid; used in peripheral vascular disorders such as Raynaud's disease, acrocyanosis, and chilblains.
(05 Mar 2000)
nicoumalone <chemical> A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin.
Pharmacological action: anticoagulant.
Chemical name: 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-
(12 Dec 1998)
nictation Winking.
Synonym: nictation.
Origin: L. Nicto, pp. -atus, to wink, fr. Nico, to beckon
(05 Mar 2000)
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nictitating membrane A thin membrane that can be drawn across the eye.
Ãâó: www.geocities.com/Heartland/Bluffs/8071/reptile/te...
niche The environment of an organism and its adaptive response to that environment.
Ãâó: highered.mcgraw-hill.com/sites/0072549238/student_...
nick translation A procedure for labelling DNA. A DNA fragment is treated with DNase to produce single-stranded nicks. The nick is moved along the DNA molecule in the presence of labelled deoxyribonucleoside triphosphates by the concerted action of the 5?> 3?exonuclease and 5?> 3?polymerase activities of E. coli DNA polymerase I.
Ãâó: www.fao.org/docrep/003/X3910E/X3910E17.htm
nick Verb: To break a phospho-diester bond in the backbone of one of the strands of a duplex DNA molecule. cf cleave; cut.
Ãâó: www.fao.org/docrep/003/X3910E/X3910E17.htm
nick translation A DNA probe labeling technique based on the introduction of nucleotide gaps into one strand of double-stranded DNA by a treatment with a nuclease, followed by the use of a DNA polymerase with exonuclease activity to extend the gaps and replace the nucleot
Ãâó: www.genpromag.com/Glossary~LETTER~N.html
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NIC low-paying
NIC having no real backing
NIC an alloy whose main constituent is nickel
NIC a rechargeable battery with a nickel cathode and a cadmium anode
NIC a storage battery having a nickel oxide cathode and an iron anode with an electrolyte of potassium hydroxide
NIC a storage battery having a nickel oxide cathode and an iron anode with an electrolyte of potassium hydroxide
NIC a cabinet containing an automatic record player
NIC the sound made by a horse
NIC characteristic of horses
NIC hard shiny gray seed of a bonduc tree
NIC hard shiny gray seed of a bonduc tree
NIC United States golfer considered by many to be the greatest golfer of all time (born in 1940)
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