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inbreeding A mating system involving the mating or breeding of closely related individuals, the most extreme form of which is self-fertilization. It is used to "fix" economically useful genetic traits in genetically improved populations; however, it also can result in fixation of deleterious recessive alleles. (See on "Ex Situ Conservation")
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inborn e. of metabolism a genetically determined biochemical disorder in which a specific enzyme defect produces a metabolic block that may have pathologic consequences at birth (e.g., phenylketonuria) or in later life (e.g., diabetes mellitus); called also enzymopathy.
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inborn error of m. see under error.
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inborn lysosomal d. lysosomal storage d.
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inborn r. unconditioned response.
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