| antigens, CD8 | <immunology> Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. Cd8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in major histocompatibility complex class I-restricted interactions. (12 Dec 1998) |
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| antigens, CD80 | <immunology> The natural ligand for the T-cell antigen CD28 (antigens, CD28) mediating t-cell and B-cell adhesion. Cd80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and ctla-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production. (12 Dec 1998) |
| antigens, CD95 | <immunology> Differentiation antigens expressed on a variety of cell lines including myeloid and lymphoblastoid cell lines. Their primary role is to regulate peripheral immune responses, which is achieved by triggering apoptosis. (12 Dec 1998) |
| antigens, differentiation | Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation. (12 Dec 1998) |
| antigens, differentiation, b-lymphocyte | Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumours of B-cell origin. (12 Dec 1998) |
| antigens, differentiation, myelomonocytic | Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukaemias and lymphomas. (12 Dec 1998) |
| antigens, differentiation, t-lymphocyte | Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function. (12 Dec 1998) |
| antigens, fungal | Substances of fungal origin that have antigenic activity. (12 Dec 1998) |
| antigens, helminth | Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes. (12 Dec 1998) |
| antigens, heterophile | Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species. (12 Dec 1998) |
| antigens, human platelet | Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy. (12 Dec 1998) |
| antigens, ly | A group of lymphocyte surface antigens differentially located on subpopulations of mouse lymphocytes. This localization has been useful in distinguishing different functional subpopulations of lymphocytes. For example, cytotoxic T-cells bear primarily lyt-23 on their surface and not lyt-1, whereas helper cells bear lyt-1 and not lyt-23. (12 Dec 1998) |
| antigens, neoplasm | Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumour cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin. (12 Dec 1998) |
| antigens, polyomavirus transforming | Polyomavirus antigens which cause infection and cellular transformation. The large t antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle t antigen for the transformation of primary cells. Small t antigen is necessary for the completion of the productive infection cycle. (12 Dec 1998) |
| antigens, protozoan | Any part or derivative of any protozoan that elicits immunity; malaria (plasmodium) and trypanosome antigens are presently the most frequently encountered. (12 Dec 1998) |