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fructose-1,6-bisphosphatase an enzyme of the hydrolase class that catalyzes the hydrolysis of fructose 1,6-bisphosphate to form fructose 6-phosphate. The reaction is part of the route of gluconeogenesis in the liver and kidneys. In EC nomenclature, called fructose-bisphosphatase.
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fructose-1,6-bisphosphatase deficiency an autosomal recessive disorder marked by apnea, hyperventilation, hypoglycemia, ketosis, and lactic acidosis resulting from impaired gluconeogenesis due to deficiency of hepatic fructose-1,6-bisphosphatase; it may be fatal to newborns, but patients past early childhood develop normally.
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fructose-2,6-bisphosphatase fructose-2,6-bisphosphate 2-phosphatase.
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fructose-2,6-bisphosphate 2-phosphatase [EC 3.1.3.46] an enzyme activity that catalyzes the hydrolysis of fructose 2,6-bisphosphate to form fructose 6-phosphate; it occurs on the same polypeptide as the enzyme activity 6-phosphofructo-2-kinase (q.v.); in liver, the two activities form part of a mechanism for regulating carbohydrate metabolism. The liver enzyme activity is activated via phosphorylation by cyclic-AMP–dependent protein kinase, thus increasing the rate of removal of fructose 2,6-bisphosphate and slowing glycolysis. Called also fructose-2,6-bisphosphatase.
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fructose-bisphosphatase [EC 3.1.3.11] EC nomenclature for fructose-1,6-bisphosphatase.
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