| fibrin tissue adhesive | <chemical> An autologous or commercial tissue adhesive containing fibrinogen and thrombin. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, factor viii, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agent such as aprotinin. Mixing of the two components promotes clotting and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, haemostasis, and wound healing. Pharmacological action: haemostatics, tissue adhesives. (12 Dec 1998) |
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| fibrin-stabilizing factor | <chemical> Fibrin stabilizing factor. It is a glycoprotein activated by thrombin in the presence of calcium to form factor xiiia. Factor xiii is found evenly distributed between plasma and platelets. Its function is to stabilise the formation of the fibrin polymer (clot) which culminates the coagulation cascade. Chemical name: Blood-coagulation factor XIII (12 Dec 1998) |
| fibrinase | 1. Former term for factor XIII. Synonym: plasmin. (05 Mar 2000) |
| fibrination | <medicine> The state of acquiring or having an excess of fibrin. Source: Websters Dictionary (01 Mar 1998) |
| fibrine | Belonging to the fibres of plants. Source: Websters Dictionary (01 Mar 1998) |
| fibrino- | Fibrin. Origin: L. Fibra, fibre (05 Mar 2000) |
| fibrinocellular | Composed of fibrin and cells, as in certain types of exudates resulting from acute inflammation. (05 Mar 2000) |
| fibrinogen | <protein> Soluble plasma protein (340 kD, 46 nm long), composed of 6 peptide chains (2 each of A_, B_ and _) and present at about 2-3 mg/ml. (12 Nov 1997) |
| fibrinogen-fibrin conversion syndrome | <syndrome> A syndrome characterised by hypofibrinogenaemia with incoagulable blood; it may be seen in abruptio placentae, prolonged retention of a dead foetus in an Rh-isosensitised mother, haemolytic blood reactions, bilateral renal cortical necrosis, and cases of trauma. (05 Mar 2000) |
| fibrinogenaemia | An increased level of fibrinogen in the blood. Synonym: fibrinogenaemia. (05 Mar 2000) |
| fibrinogenase | <enzyme> Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. (18 Nov 1997) |
| fibrinogenesis | Formation or production of fibrin. (05 Mar 2000) |
| fibrinogenic | <physiology> Possessed of properties similar to fibrinogen; capable of forming fibrin. Pertaining to fibrinogen, producing fibrin. (12 May 2002) |
| fibrinogenolysis | The inactivation or dissolution of fibrinogen in the blood. Origin: fibrinogen + G. Lysis, dissolution (05 Mar 2000) |
| fibrinogenopenia | A concentration of fibrinogen in the blood that is less than the normal. Origin: fibrinogen + G. Penia, poverty (05 Mar 2000) |