| beta-hydroxy-beta-methylglutaryl-CoA | -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000) |
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| bile acid-CoA ligase | <enzyme> Catalyses the synthesis of all bile acid-coas; in order to measure the activity of all bile acids, the bile acid is coupled with c(14)-glycine and measured with bile acid-CoA glycine-taurine n-acetyltransferase Registry number: EC 6.2.1.- (26 Jun 1999) |
| branched chain acyl-CoA oxidase | <enzyme> Enzyme from human liver peroxisomes acts on both 2-methyl branched fatty acyl- and bile acid-CoA intermediates, unlike rat liver peroxisomes which have separate enzymes for branched chain fatty acids (pristanoyl-CoA) and bile acid-CoA; involved in beta-oxidation of fatty acids and bil Registry number: EC 1.3.3.- Synonym: 2-methyl-branched chain acyl-CoA oxidase, hbrcacox (26 Jun 1999) |
| butyrate-CoA ligase | Fatty acid thiokinase (medium chain), a ligase forming acyl-CoA's from medium-chain fatty acids and CoA with the conversion of ATP to AMP and PPi. A key step in activation of fatty acids. Synonym: acyl-activating enzyme, butyryl-CoA synthetase, octanoyl-CoA synthetase. (05 Mar 2000) |
| butyryl-CoA | CH3CH2CH2COSCoA;condensation product of coenzyme A and n-butanoic acid; an intermediate in fatty acid degradation and in biosynthesis. (05 Mar 2000) |
| butyryl-CoA dehydrogenase | <enzyme> Electron-transferring flavoprotein system reducing ubiquinone and other acceptors; formerly EC 1.3.2.1; a short-chain acyl-CoA dehydrogenase Registry number: EC 1.3.99.2 Synonym: butyryl dehydrogenase, butyryl-coenzyme a dehydrogenase (26 Jun 1999) |
| butyryl-CoA synthetase | Fatty acid thiokinase (medium chain), a ligase forming acyl-CoA's from medium-chain fatty acids and CoA with the conversion of ATP to AMP and PPi. A key step in activation of fatty acids. Synonym: acyl-activating enzyme, butyryl-CoA synthetase, octanoyl-CoA synthetase. (05 Mar 2000) |
| caffeoyl-CoA O-methyltransferase | <enzyme> Catalyses the methylation of caffeoyl-CoA to form trans-feruloyl-CoA; also accepts with low affinity various other caffeic esters as substrates; do not confuse with EC 2.1.1.68 which acts on caffeic acid; has been sequenced; genbank l22203 (stellaria longipes) Registry number: EC 2.1.1.104 Synonym: sam-c-CoA 3-o-methyltransferase, s-adenosylmethionin-trans-caffeoyl-coenzyme a 3-o-methyltransferase, sam-cca-methyltransferase, caffeoyl-CoA-3-o-methyltransferase, s-adenosyl-l-methionine-trans-caffeoyl-coenzyme a 3-o-methyltransferase, ccoaomt, s-adenosylmethionine-trans-caffeoyl-CoA 3-o-methyltransferase, ccoamt (26 Jun 1999) |
| palmitoyl-CoA dependent dehydrogenase | <chemical> Sum of reactions catalyzed by fatty acyl-CoA oxidase, enoyl-CoA hydratase (EC 4.2.1.17) and beta-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) Synonym: palmitoyl-coenzyme a dependent dehydrogenase (26 Jun 1999) |
| palmitoyl-CoA hydrolase | <enzyme> Enzyme catalyzing reversibly the hydrolysis of palmitoyl-CoA or other long-chain acyl coenzyme a compounds to yield CoA and palmitate or other acyl esters. The enzyme is involved in the esterification of fatty acids to form triglycerides. Chemical name: Palmitoyl-CoA hydrolase Registry number: EC 3.1.2.2 (12 Dec 1998) |
| palmitoyl CoA oxidase | <enzyme> In peroxisomes; forms hydrogen peroxide Registry number: EC 1.3.3.- Synonym: palmityl CoA oxidase, palmitoyl coenzyme a oxidase (26 Jun 1999) |
| malonyl-CoA | The condensation product of malonic acid and coenzyme A, an intermediate in fatty acid biosynthesis. <chemical> S-malonylcoenzyme A. A coenzyme a derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. Chemical name: Coenzyme A, S-(hydrogen propanedioate) Synonym: malonylcoenzyme A. (05 Mar 2000) |
| malonyl-CoA-3,4-dichloroaniline N-malonyltransferase | <enzyme> From peanuts Registry number: EC 2.3.1.- Synonym: 3,4-dichloroaniline n-malonyltransferase, dca malonyltransferase, malonyl-coenzyme a-3,4-dichloroaniline n-malonyltransferase (26 Jun 1999) |
| malonyl-CoA-anthranilic acid N-malonyltransferase | <enzyme> From peanuts Registry number: EC 2.3.1.- Synonym: anthranilic acid n-malonyltransferase, aa malonyltransferase, malonyl-coenzyme a-anthranilic acid n-malonyltransferase (26 Jun 1999) |
| malonyl-CoA-D-tryptophan N-malonyltransferase | <enzyme> From peanuts Registry number: EC 2.3.1.- Synonym: trp-malonyltransferase, malonyl-coenzyme a-d-tryptophan n-malonyltransferase (26 Jun 1999) |