| 3-hydroxybenzoate-6-hydroxylase | <enzyme> From micrococcus; a flavoprotein; catalyses reversibly the hydroxylation of 3-hydroxybenzoate in the presence of NADH and o2 to form 2,5-dihydroxybenzoate, nad and h2o Registry number: EC 1.14.13.24 Synonym: 3-hydroxybenzoate-6-monooxygenase, 3-ohb-6-hydroxylase, 3-hydroxybenzoate 6-hydroxylase (26 Jun 1999) |
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| 3-hydroxybutanoic acid | CH3CH(OH)CH2COOH;the d-stereoisomer is one of the ketone bodies and is formed in ketogenesis; it is an important fuel for extrahepatic tissues; as an acyl derivative it is also an intermediate in fatty acid biosynthesis. The l-isomer is found as a coenzyme A derivative in b oxidation of fatty acids. Synonym: 3-hydroxybutanoic acid, beta-hydroxybutyric acid. D-3-hydroxybutyric acid dehydrogenase, an enzyme that reversibly catalyses the interconversion of the two main ketone bodies, catalyzing acetoacetate + NADH + H+ &dblarr; d-3-hydroxybutyrate + NAD+. (05 Mar 2000) |
| 3-hydroxybutyric acid | CH3CH(OH)CH2COOH;the d-stereoisomer is one of the ketone bodies and is formed in ketogenesis; it is an important fuel for extrahepatic tissues; as an acyl derivative it is also an intermediate in fatty acid biosynthesis. The l-isomer is found as a coenzyme A derivative in b oxidation of fatty acids. Synonym: 3-hydroxybutanoic acid, beta-hydroxybutyric acid. D-3-hydroxybutyric acid dehydrogenase, an enzyme that reversibly catalyses the interconversion of the two main ketone bodies, catalyzing acetoacetate + NADH + H+ &dblarr; d-3-hydroxybutyrate + NAD+. (05 Mar 2000) |
| 3-hydroxycholanate dehydrogenase | <enzyme> Reduce keto groups to hydroxyl groups reversibly Registry number: EC 1.1.1.52 (26 Jun 1999) |
| 3-hydroxyglutaric acid | HOOCCH2CH(OH)CH2COOH;accumulates in individuals with glutaric acidemia type I. (05 Mar 2000) |
| 3-hydroxyphenylacetate 6-hydroxylase | <chemical> Fad-dependent monooxygenase from a flavobacterium species; requires nadhor NADPH; forms 2,5-dihydroxyphenylacetate (26 Jun 1999) |
| 3-hydroxypicolinic acid-AMP ligase | <enzyme> From cell extracts of streptomyces pristinaespiralis; activates the first pristinamycin 1 residue 3-hydroxypicolinic acid; shows 58% nh2-terminal amino acid sequence identity with s. Griseoviridus 3-hpa-activating enzyme; amino acid sequence given in first source (page 709) Registry number: EC 6.3.2.- Synonym: pi synthetase 1, snba protein, pristinamycin I synthetase 1,3-hpa-AMP ligase (26 Jun 1999) |
| 3-hydroxyproline | A derivative of proline found in certain collagens, particularly basement membrane collagen. Synonym: 3-hydroxy-2-pyrrolidinecarboxylic acid. (05 Mar 2000) |
| 3-hydroxysteroid dehydrogenases | <enzyme> Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids. Registry number: EC 1.1.- (12 Dec 1998) |
| 3-hydroxytyramine | <drug> A catecholamine neurotransmitter and hormone (153 D), formed by decarboxylation of dehydroxyphenylalanine (dopa). A precursor of adrenaline and noradrenaline. Pharmacologic action: 1. Precursor of norepinephrine 2. Stimulates dopaminergic, alpha and beta-1 adrenergic receptors: 3. Dopaminergic (1-2 mcg/kg per min): cerebral, renal, and mesenteric vasodilation increase urine output 4. Mixed alpha and beta-1 (2-10 mcg/kg per min): increases cardiac ouput with moderate increase systemic vascular resistance 5. Predominantly alpha (>20 mcg/kg per min): increases systemic vascular resistance Uses: 1. Treat hypotension associated with bradycardia 2. Stimulate cardiac output and urine output Dose: 1. Start infusion at 1-5 mcg/kg per min and titrate to effect. 2. Use the lowest dose that provides the desired hemodynamic improvement. 3. Do not exceed 20 mcg/kg per min. Potential complications: 1. May increase pulmonary pressure and worsen pulmonary congestion. 2. May increase myocardial work without improving coronary blood flow, exacerbating myocardial ischemia 3. Stimulates heart rate and may cause supraventricular or ventricular arrhythmias (15 Mar 2000) |
| 3-iodo-1,2-propanediol | An organic form of iodine which slowly liberates iodine in the body after oral administration. Used primarily as an expectorant/mucolytic. Synonym: 3-iodo-1,2-propanediol, gamma-iodopropyleneglycol. (05 Mar 2000) |
| 3-iodobenzylguanidine | <chemical> A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumours. The radiolabelled forms are used as antineoplastic agent and radioactive imaging agents. (merck index, 12th ed) mibg serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase. Pharmacological action: antineoplastic agent, enzyme inhibitors, radiopharmaceuticals, sympatholytics. (12 Dec 1998) |
| 3-isopropylcatechol 2,3-dioxygenase | <enzyme> Isolated from rhodococcus erythropolis; genbank u24277 Registry number: EC 1.- Synonym: ipbc gene product, 3-ipc 2,3-dioxygenase (26 Jun 1999) |
| 3-isopropylmalate dehydrogenase | <enzyme> Leub gene product isolated from thermus thermophilus Registry number: EC 1.1.1.85 Synonym: beta-isopropylmalate dehydrogenase, impdh, leub gene product, leu2 gene product (26 Jun 1999) |
| 3-ketoacid-CoA transferase | <enzyme> An enzyme catalyzing the reversible conversion of acetoacetyl-CoA and succinate into succinyl-CoA and acetoacetate; malonyl-CoA can substitute for succinyl-CoA and a few other 3-oxo acids for the acetoacetate; an important step in order for the ketone bodies to serve as a fuel for extrahepatic tissues. Synonym: 3-ketoacid-CoA transferase, acetoacetyl-succinic thiophorase. (05 Mar 2000) |