| trypanosomiasis | <disease, microbiology> A parasitic disease caused by the American strain, Trypanosoma cruzi. Chagas disease is usually transmitted by the bite of the kissing bug, but may also follow breast feeding (to infants) and blood transfusion. Although much more common in South America, it does, on rare occasions, occur in the U.S. A nodular swelling (chagoma) appears at the site of inoculation following a bite. The acute phase of the disease can last 2 to 3 months and patients present with fever, headache, anorexia, conjunctivitis and myocarditis. Infants can develop meningitis and heart involvement. Trypanosomiasis can cause congestive heart failure and ventricular aneurysms. Treatment is with nifurtimox. (27 Sep 1997) |
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| trypanosomiasis, african | A disease endemic among people and animals in central africa. It is caused by various species of trypanosomes, particularly t. Gambiense and t. Rhodesiense. Its second host is the tsetse fly. Involvement of the central nervous system produces "african sleeping sickness." nagana is a rapidly fatal trypanosomiasis of horses and other animals. (12 Dec 1998) |
| trypanosomiasis, bovine | Infection in cattle caused by various species of trypanosomes. (12 Dec 1998) |
| trypanosomic | Relating to trypanosomes, especially denoting infection by such organisms. (05 Mar 2000) |
| trypanosomicide | An agent that kills trypanosomes. Synonym: trypanicide, trypanosomicide. Origin: trypanosome + L. Caedo, to kill (05 Mar 2000) |
| trypanosomid | A skin lesion resulting from immunologic changes from trypanosome disease. Origin: trypanosome + G. -id (05 Mar 2000) |
| trypanothione synthetase | <enzyme> Catalyses the synthesis of n(1)- and n(8)-glutathionylspermidine and trypanothione from ATP/mg, glutathione, and spermidine; purified from crithidia fasciculata; member of ATP-dependent class of ligases forming an amide linkage Registry number: EC 6.3.1.- (26 Jun 1999) |
| tryparsamide | Sodium N-carbamylmethyl-p-aminobenzenearsonate;used in the treatment of trypanosomic and spirochetal infections, especially neurosyphilis, and the late stages of African sleeping sickness. (05 Mar 2000) |
| trypomastigote | Term to replace the older term, "trypanosome stage," which was often confused with the flagellate genus Trypanosoma. It denotes the stage (infective stage for South American trypanosomiasis and African trypanosomiasis, and the only stage found in man in the latter illness) in which the flagellum arises from a posteriorly located kinetoplast and emerges from the side of the body, with an undulating membrane running along the length of the body. Origin: G. Trypanon, auger, + mastix, whip (05 Mar 2000) |
| trypsin | <enzyme> Serine protease from the pancreas of vertebrates. Cleaves peptide bonds involving the amino groups of lysine or arginine. (18 Nov 1997) |
| trypsin G-banding stain | <technique> A unique chromosome staining technique, used in human cytogenetics to identify individual chromosomes, which produces characteristic bands. It utilises acetic acid fixation, air drying, denaturing chromosomes mildly with proteolytic enzymes, salts, heat, detergents, or urea, and finally Giemsa stain; chromosome bands appear similar to those fluorochromed by Q-banding stain. Synonym: Giemsa chromosome banding stain. (05 Mar 2000) |
| trypsin inhibitor | A peptide hydrolyzed off trypsinogen under the catalytic influence of enteropeptidase, with trypsin produced as a result; so called because the peptide masks or inhibits the active site of the trypsin molecule, one of the polypeptides, from various sources (e.g., human and bovine colostrum, soybeans, egg white), that inhibit the action of trypsin. Compare: Bowman-Birk inhibitor. (05 Mar 2000) |
| trypsin inhibitor, bowman-birk soybean | <chemical> A low-molecular-weight protein (minimum molecular weight 8000) which has the ability to inhibit trypsin as well as chymotrypsin at independent binding sites. It is characterised by a high cystine content and the absence of glycine. Pharmacological action: trypsin inhibitors. (12 Dec 1998) |
| trypsin inhibitor, kazal pancreatic | <chemical> A pancreatic trypsin inhibitor common to all mammals. It is secreted with the zymogens into the pancreatic juice. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the kunitz bovine pancreatic trypsin inhibitor (aprotinin). Chemical name: Trypsin inhibitor, pancreatic secretory (12 Dec 1998) |
| trypsin inhibitor, kunitz soybean | <chemical> A high-molecular-weight protein (approximately 22,500) containing 198 amino acid residues. It is a strong inhibitor of trypsin and human plasmin. Pharmacological action: trypsin inhibitors. Chemical name: Trypsin inhibitor, Kunitz soybean (12 Dec 1998) |