| thioglycolic acid | HSCH2COOH;used as a reagent for the detection of metals such as iron, molybdenum, silver, and tin; the ammonium and sodium salts are used in home permanents, the calcium salt as a depilatory. Synonym: mercaptoacetic acid. (05 Mar 2000) |
|---|---|
| thioguanine | <chemical> 2-amino-1,7-dihydro-6h-purine-6-thione. An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukaemia. Pharmacological action: antimetabolites, antineoplastic. Chemical name: 6H-Purine-6-thione, 2-amino-1,7-dihydro- (12 Dec 1998) |
| thioinosine | <chemical> 9-beta-d-ribofuranosyl-9h-purine-6-thiol. Sulfhydryl analog of inosine that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to mercaptopurine in the treatment of leukaemia. Pharmacological action: antimetabolites, antimetabolites, antineoplastic, immunosuppressive agents. Chemical name: Inosine, 6-thio- (12 Dec 1998) |
| thiokinase | Group term for enzymes that form acyl-CoA compounds from the corresponding fatty acids and CoA; the bond is through the sulfur atom of the CoA. (05 Mar 2000) |
| thiol | 1. The monovalent radical -SH when attached to carbon; a hydrosulfide; a mercaptan. 2. A mixture of sulfurated and sulfonated petroleum oils purified with ammonia; used in the treatment of skin diseases. (05 Mar 2000) |
| thiol activated haemolysins | Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function. Oxidation (to disulphide bridges) inactivates the toxin. Examples: tetanolysin, streptolysin O, _ toxin, cereolysin. (18 Nov 1997) |
| thiol beta-lactamase | <enzyme> Active site serine has been mutated to cysteine in e. Coli Registry number: EC 3.5.2.- (26 Jun 1999) |
| thiol endopeptidase | Proteases that have an active thiol group. Includes papain and ficin. (18 Nov 1997) |
| thiol enzyme | <enzyme> An enzyme whose activity depends on a free thiol group. (05 Mar 2000) |
| thiol ester | An ester formed from a carboxylic acid and a thiol (i.e., RCO-SR') e.g., acetyl-coenzyme A. (05 Mar 2000) |
| thiol proteinase | Proteases that have an active thiol group. Includes papain and ficin. (18 Nov 1997) |
| thiol-dependent peroxidase | <enzyme> From giardia intestinalis, which lacks glutathione; enzyme can also act with exogenous glutathione Registry number: EC 1.11.1.- Synonym: glutathione-linked thiol peroxidase (26 Jun 1999) |
| thiolase | An acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis. Synonym: acetoacetyl-CoA thiolase, acetyl-CoA thiolase, thiolase. (05 Mar 2000) |
| thiole | <chemistry> A sulphur hydrocarbon, C4H4S, analogous to furfuran and benzene, and acting as the base of a large number of substances which closely resemble the corresponding aromatic derivatives. Origin: Thio- + phenyl + -ene. Source: Websters Dictionary (01 Mar 1998) |
| thiolester hydrolases | <enzyme> Registry number: EC 3.1.2. (12 Dec 1998) |