| MN | a blood group in the MNSs blood group system; malignant nephrosclerosis; Master of Nursing; meganewt... |
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| MND | minimum necrosing dose; minor neurological dysfunction; modified neck dissection; motor neuron disea... |
| NBA | neuron-binding activity |
| NSE | neuron-specific enolase; nonspecific esterase; normal saline enema |
| NSM | neurosecretory material; neurosecretory motor neuron; nonantigenic specific mediator; nutrient sporu... |
perikaryion of neurofilament
perikaryon
| unipolar neuron | A neuron whose cell body emits a single axonal process resulting from the fusion of two polar processes during development; at a variable distance from the cell body, the process divides into a peripheral axon branch extending outward as a peripheral afferent (sensory) nerve fibre, and a central axon branch that enters into synaptic contact with neuron's in the spinal cord or brainstem. With the single known exception of the neuron's composing the mesencephalic nucleus of the trigeminus, unipolar neuron's are the exclusive neural elements of the sensory ganglia. The lack of dendritic processes of these primary sensory neuron's is only apparent: the dendritic pole of the unipolar neuron is represented by the unmyelinated terminal ramifications of the peripheral axon branch. Synonym: pseudounipolar cell, pseudounipolar neuron, unipolar cell. (05 Mar 2000) |
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| upper motor neuron | Clinical term indicating those neuron's of the motor cortex that contribute to the formation of the pyramidal or corticospinal and corticobulbar tracts, as distinguished from the lower motor neuron's innervating the skeletal muscles. Although not motor neuron's in the strict sense, these cortical neuron's became colloquially classified as motor neuron's because their stimulation produces movement and their destruction causes severe disorders of movement. See: motor neuron, motor cortex. (05 Mar 2000) |
| upper motor neuron lesion | Injury to cerebral descending (corticonuclear) fibres above the brainstem or spinal motor nerve nucleus. Synonym: upper motor neuron lesion. (05 Mar 2000) |
| lower motor neuron | Clinical term used to indicate the final motor neuron's that innervate the skeletal muscles; distinguished from upper motor neuron's of the motor cortex that contribute to the pyramidal or corticospinal tract. See: motor neuron. (05 Mar 2000) |
| lower motor neuron dysarthria | Dysarthria caused by dysfunction of the motor nuclei and the lower pons or medulla, or other neural connections, central and peripheral to the muscles of articulation. (05 Mar 2000) |
| lower motor neuron lesion | Injury to motor cells in the brainstem or spinal cord, or of the axons derived from them. (05 Mar 2000) |
| bilaterally small, smooth kidneys | <radiology> Generalised atherosclerosis, nephrosclerosis - benign and malignant, atheroembolic renal disease, chronic glomerulonephritis, papillary necrosis, hereditary diseases, hereditary chronic nephritis (Alport's syndrome), medullary cystic disease, amyloidosis (late), arterial hypotension Cf: other urographic patterns (12 Dec 1998) |
| carcinoma, non-small-cell lung | A heterogeneous aggregate of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. They are dealt with collectively because of the shared properties of poor response to conventional chemotherapy and the potential for cure with surgical resection in a fraction of patients. (12 Dec 1998) |
| carcinoma, small cell | An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterised by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. There are admixtures of small cell lung carcinoma with other types of lung cancer. Small cell carcinomas are distinguished by their distinctive biological features, response to chemotherapy and radiotherapy, and by their nearly universal tendency to develop overt or subclinical metastases, which frequently eliminates surgery in most patients. (12 Dec 1998) |
| generalised small bowel disease | <radiology> Hypoproteinaemia, sprue, Whipple (12 Dec 1998) |
| mesenteric portion of small intestine | The freely movable portion of the small intestine supplied with a mesentery, comprising the jejunum and ileum. Synonym: mesenteric portion of small intestine. (05 Mar 2000) |
| ribonucleoproteins, small nuclear | Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm. The u3 snrnp is localised in the nucleolus, where it aligns into base pairs with the 28s rrna precursor in a still unidentified region and functions in pre-rrna processing. The u7 snrnp aligns into base pairs with a conserved sequence in the 3'-end of histone pre-mRNA and is an essential cofactor for the cleavage that creates the mature nonadenylated 3'-end. (12 Dec 1998) |
| ribonucleoproteins, small, u1 | A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the u1 snrnp along with other small ribonucleoproteins (u2, u4-u6, and u5) assemble into spliceosomes that remove introns from pre-mRNA by splicing. The u1 snrnp base pairs with conserved sequence motifs at the 5'-splice site and recognises both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction. (12 Dec 1998) |
| ribonucleoproteins, small, u2 | A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the u2 snrnp along with other small ribonucleoproteins (u1, u4-u6, and u5) assemble into spliceosomes that remove introns from pre-mRNA by splicing. The u2 snrnp base pairs with conserved sequence motifs at the branch point, which associates with a heat- and rnaase-sensitive factor in an early step of splicing. (12 Dec 1998) |
| ribonucleoproteins, small, u4-u6 | A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the u4-u6 snrnp along with the u5 snrnp preassemble into a single 25s particle that binds to the u1 and u2 snrnps and the substrate to form mature spliceosomes. There is also evidence for the existence of individual u4 or u6 snrnps in addition to their organization as a u4-u6 snrnp. (12 Dec 1998) |