| ROW | Rendu-Osler-Weber [syndrome]; rest of the world |
|---|---|
| RP | radial pulse; radiopharmaceutical; rapid processing [of film]; Raynaud phenomenon; reactive protein;... |
| R&R | rate and rhythm; rest and recuperation |
| RT | radiologic technologist; radiotelemetry; radiotherapy; radium therapy; rapid tranquilization; reacti... |
| SBR | small bowel resection; spleen-to-body [weight] ratio; strict bed rest; styrene-butadiene rubber |
| restriction endonuclease | <enzyme, molecular biology> Class of bacterial enzymes that cut DNA at specific sites. In bacteria their function is to destroy foreign DNA, such as that of bacteriophages (host DNA is specifically modified at these sites). Type I restriction endonucleases occur as a complex with the methylase and a polypeptide that binds to the recognition site on DNA. They are often not very specific and cut at a remote site. Type II restriction endonucleases are the classic experimental tools. They have very specific recognition and cutting sites. The recognition sites are short, 4-8 nucleotides and are usually palindromic sequences. Because both strands have the same sequence running in opposite directions the enzymes make double stranded breaks, which, if the site of cleavage is off centre, generates fragments with short single stranded tails, these can hybridise to the tails of other fragments and are called sticky ends. They are generally named according to the bacterium from which they were isolated (first letter of genus name and the first two letters of the specific name). The bacterial strain is identified next and multiple enzymes are given Roman numerals. For example the two enzymes isolated from the R strain of E. Coli are designated Eco RI and Eco RII. (10 Mar 1998) |
|---|---|
| restriction enzyme | <enzyme, molecular biology> Class of bacterial enzymes that cut DNA at specific sites. In bacteria their function is to destroy foreign DNA, such as that of bacteriophages (host DNA is specifically modified at these sites). Type I restriction endonucleases occur as a complex with the methylase and a polypeptide that binds to the recognition site on DNA. They are often not very specific and cut at a remote site. Type II restriction endonucleases are the classic experimental tools. They have very specific recognition and cutting sites. The recognition sites are short, 4-8 nucleotides and are usually palindromic sequences. Because both strands have the same sequence running in opposite directions the enzymes make double stranded breaks, which, if the site of cleavage is off centre, generates fragments with short single stranded tails, these can hybridise to the tails of other fragments and are called sticky ends. They are generally named according to the bacterium from which they were isolated (first letter of genus name and the first two letters of the specific name). The bacterial strain is identified next and multiple enzymes are given Roman numerals. For example the two enzymes isolated from the R strain of E. Coli are designated Eco RI and Eco RII. (10 Mar 1998) |
| restriction enzyme cutting site | <molecular biology> A specific nucleotide sequence of DNA at which a particular restriction enzyme cuts the DNA. Some sites occur frequently in DNA (for example, every several hundred basepairs), others much less frequently (rare-cutter, for example, every 10,000 base pairs). (10 Mar 1998) |
| restriction enzyme, endonuclease | A protein that recognises specific, short nucleotide sequences and cuts DNA at those sites. Bacteria contain over 400 such enzymes that recognise and cut over 100 different DNA sequences. See restriction enzyme cutting site. (05 Mar 2000) |
| restriction fragment | <molecular biology> The fragments of DNA generated by digesting DNA with a specific restriction endonuclease. Each of the fragments ends in a site recognised by that specific enzyme. (10 Mar 1998) |
| restriction fragment length polymorphism | <molecular biology, technique> A method that allows familial relationships to be established by comparing the characteristic polymorphic patterns that are obtained when certain regions of genomic DNA are amplified (typically by PCR) and cut with certain restriction enzymes. The variation in the length of DNA fragments produced by a restriction endonuclease that cuts at a polymorphic locus. Such variations are generated by mutations that create or abolish recognition sites for these enzymes. This is a key tool in DNA fingerprinting, reflecting the existence of different alleles in the individual. Restriction fragment length polymorphism mapping is also used in plant breeding to see if a key trait such as disease resistance is inherited. In principle, an individual can be identified unambiquously by restriction fragment length polymorphism hence the use of restriction fragment length polymorphism in forensic analysis of blood, hair or semen). Similarly, if a polymorphism can be identified close to the locus of a genetic defect, it provides a valuable marker for tracing the inheritance of the defect. Synonym: DNA fingerprinting. Acronym: RFLP (12 Jan 1998) |
| restriction length polymorphism | Fragment length polymorphism, the existence of allelic forms recognizable by the length of fragments that result when the nucleotide chain is treated by a specific restriction enzyme that cleaves wherever a particular sequence of nucleotides occurs. A mutation in this sequence changes cleaving and hence the number of fragments. (05 Mar 2000) |
| restriction map | <molecular biology> Map of DNA showing the position of sites recognised and cut by various restriction endonucleases. (12 Jan 1998) |
| restriction mapping | Use of restriction endonucleases to analyze and generate a physical map of genomes or genes. The nucleotide sequence determined is often then translated into an amino acid sequence, providing a means for sequencing the protein for which the gene codes, or for which the mRNA is a messenger. (12 Dec 1998) |
| restriction methylation | The enzymatic addition of methyl groups to selected adenine and cytosine residues to protect from hydrolysis by certain restriction enzymes. (05 Mar 2000) |
| restriction nuclease | <enzyme, molecular biology> Class of bacterial enzymes that cut DNA at specific sites. In bacteria their function is to destroy foreign DNA, such as that of bacteriophages (host DNA is specifically modified at these sites). Type I restriction endonucleases occur as a complex with the methylase and a polypeptide that binds to the recognition site on DNA. They are often not very specific and cut at a remote site. Type II restriction endonucleases are the classic experimental tools. They have very specific recognition and cutting sites. The recognition sites are short, 4-8 nucleotides and are usually palindromic sequences. Because both strands have the same sequence running in opposite directions the enzymes make double stranded breaks, which, if the site of cleavage is off centre, generates fragments with short single stranded tails, these can hybridise to the tails of other fragments and are called sticky ends. They are generally named according to the bacterium from which they were isolated (first letter of genus name and the first two letters of the specific name). The bacterial strain is identified next and multiple enzymes are given Roman numerals. For example the two enzymes isolated from the R strain of E. Coli are designated Eco RI and Eco RII. (10 Mar 1998) |
| restriction site | A sequence in DNA that can be recognised and cut by a specific restriction enzyme. (12 Dec 1998) |
| restriction-site polymorphism | DNA polymorphism in which the sequence of one form of the polymorphism contains a recognition site for a particular endonuclease, but the sequence of the other form lacks such a site. (05 Mar 2000) |
| restrictive cardiomyopathy | <cardiology, pathology> A group of disorders which affect the heart muscle resulting in the ineffective pumping of blood. Examples include amyloidosis, Loeffler's syndrome, sarcoidosis, haemochromatosis, scleroderma and carcinoid syndrome. Complications include arrhythmias and progressive heart failure. Origin: Gr. Pathos = disease (27 Sep 1997) |
| restrictive temperature | <molecular biology> Of a temperature sensitive mutation, a temperature at which the mutated gene product behaves normally and so the cell or organism survives as if wild type. C.f. The restrictive temperature, at which the gene product takes on a mutant phenotype. (18 Nov 1997) |
| restenosis |
The gradual reclosing of an artery after it has been widened.
Ãâó: www.ehealthmd.com/library/angioplasty/AGO_glossary...
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| restriction |
A course in which the learning objectives, content and/or assessment are so similar to a second course that a student cannot be credited with both towards a certificate, diploma or degree. In some cases a restricted course may be taken and credited as COP.
Ãâó: https://ndeva.auckland.ac.nz/nDeva/Help/terminolog...
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| restriction map |
A genetic map of DNA showing the relative positions of restriction enzyme cleavage sites.
Ãâó: www.modernhumanorigins.com/r.html
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| restriction enzyme |
An endonuclease that will recognize a specific target nucleotide sequence in DNA and break the DNA chain at the target; a variety of these enzymes are known, and they are extensively used in genetic engineering.
Ãâó: helios.bto.ed.ac.uk/bto/glossary/qr.htm
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| resting spore |
A thick-walled spore, particularly one formed by a sexual process, germinating only after an extended period of dormancy (eg, an overwintering teliospore). (16)
Ãâó: ppathw3.cals.cornell.edu/glossary/Defs_R.htm
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| rest | the proprietor of a restaurant |
|---|---|
| rest | the proprietor of a restaurant |
| rest | not tired |
| rest | a person who rests |
| rest | affording or marked by rest or repose |
| rest | in a restful manner |
| rest | the attribute of being restful |
| rest | European woody plant having pink flowers and unifoliate leaves and long tough roots |
| rest | Eurasian plant having loose racemes of pink or purple flowers and spiny stems and tough roots |
| rest | the potential difference between the two sides of the membrane of a nerve cell when the cell is not conducting an impulse |
| rest | restore to a previous or better condition, as of art works or antiques |
| rest | give or bring back |
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