| Gomori's non-specific alkaline phosphatase stain | <technique> A calcium-cobalt sulfide method using frozen sections or cold acetone-or formalin-fixed paraffin sections, plus sodium beta-glycerophosphate as a substrate at pH 9.0 to 9.5 with Mg++ as activator; calcium ions precipitate the liberated phosphate, cobalt salt replaces the calcium phosphate, and ammonium sulfide converts the product to a black cobalt sulfide. (05 Mar 2000) |
|---|---|
| group-specific protease | <enzyme> A serine protease, obtained from rat small intestine, which preferentially inactivates the apo forms of certain pyridoxal phosphate requiring enzymes Registry number: EC 3.4.21.- (26 Jun 1999) |
| RNA, transfer, amino acid-specific | A group of transfer rnas which are specific for carrying each one of the 20 amino acids to the ribosome in preparation for protein synthesis. (12 Dec 1998) |
| myelencephalon-specific serine protease | <enzyme> Specifically expressed in the nervous system; plays a role in normal homeostasis and response of spinal cord to injury. Registry number: EC 3.4.21.- Synonym: myelencephalon-specific protease, msp enzyme (26 Jun 1999) |
| pregnancy-specific beta 1-glycoprotein | A glycoprotein with the electrophoretic mobility of a beta-1 globulin. It is produced by the placental trophoblast and secreted into the maternal bloodstream during pregnancy. It can be detected 18 days after ovulation and its concentration in plasma rises steadily until, at the end of gestation, it reaches 200 mg/ml. It has been proposed as a measure of placental function for fertility control and is a candidate for an early pregnancy test. (12 Dec 1998) |
| prenylated peptide-specific endoprotease | <enzyme> Cleaves c-terminal tripeptide from prenylated protein having c-terminal sequence caax; race is rac and a-factor converting enzyme with same activity Registry number: EC 3.4.14.- Synonym: prenylated protein endoprotease, race enzyme, isoprenylated protein endopeptidase, isoprenylated protein endoprotease (26 Jun 1999) |
| cytosol non-specific dipeptidase | <enzyme> Also referred to as peptidase a (see synonym to penicillopepsin, EC 3.4.23.20) Registry number: EC 3.4.13.- Synonym: glycyl-l-leucine hydrolase, glycylleucine dipeptidase, gly-leu dipeptide peptidase, dipeptide hydrolase, glycyl-leucine dipeptidase (26 Jun 1999) |
| cytotoxic T lymphocyte-specific serine protease | <enzyme> Structural sequence given in first source Registry number: EC 3.4.21.- Synonym: cytotoxic t lymphocyte-specific serine protease ccp I, cytotoxic t lymphocyte specific serine protease ccp II, mast cell protease type II (26 Jun 1999) |
| proline-specific dipeptidylcarboxypeptidase | <enzyme> From streptomyces species; removes diproline form c-terminus of proline-containing peptides such as boc-pro-pro-pro-pro or leu-pro-pro-pro-pro-pro Registry number: EC 3.4.15.- Synonym: pro-dpp-carboxypeptidase (26 Jun 1999) |
| prostate-specific antigen | <tumour marker> A simple blood test used to detect prostate cancer in men. The test measures a specific antigen normally secreted by the prostate. If cancer is developing, the prostate secretes greater amounts of prostate-specific antigen. This test is recommended for men with an enlarged prostate and an increased risk of prostate cancer. It is an enzyme that is produced by epithelial cells of both benign and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer. It is a single chain 31 kilodalton glycoprotein with 240 amino acid residues and 4 carbohydrate side chains that is a kallikrein protease. It is found in normal seminal fluid and produced by the prostatic epithelial cells. Elevated levels in blood serum are associated with prostatic enlargement and prostatic adenocarcinoma, and this allows early detection of cancer in many cases. In about 70% of cases, the rise is due to a cancerous condition. No large scale clinical studies have been completed to assess the impact of testing on survival from prostate cancer, and the medical and economic value of testing remain uncertain. Acronym: PSA Registry number: EC 3.4.21.77 (22 Sep 2002) |
| pyrimidine-guanine sequence-specific ribonuclease | <enzyme> From yolk granules of adult rana catesbeiana oocytes Registry number: EC 3.1.27.- Synonym: rc-rnase, rana catesbeiana rnase (26 Jun 1999) |
| site-specific mutagenesis | <cell culture, molecular biology> An in vitro technique in which an alteration is made at a specific site in a DNA molecule, which is then reintroduced into a cell. Various techniques are used, for the cell biologist, a very powerful approach to determining which parts of a protein or nucleotide sequence are critical to function. (18 Nov 1997) |
| site specific mutation | An alteration of the structure of a gene at a specific sequence, usually referring to experimentally produced changes in gene sequence. (05 Mar 2000) |
| site-specific recombination | <molecular biology> A type of recombination that occurs between two specific short DNA sequences present in the same or in different molecules. An example is the integration and excision of _ prophage. (18 Nov 1997) |
| soluble specific substance | A soluble type-specific polysaccharide produced during active growth of virulent pneumococci composing a large part of the capsule. Synonym: pneumococcal polysaccharide, soluble specific substance, specific soluble polysaccharide, specific soluble sugar. (05 Mar 2000) |