| secondary adhesion | Delayed closure of two granulating surfaces. Synonym: secondary adhesion, secondary union. (05 Mar 2000) |
|---|---|
| differential adhesion | The differential adhesion hypothesis was advanced by Steinberg to explain the mechanism by which heterotypic cells in mixed aggregates sort out into isotypic territories. Quantitative differences in homo and hetero typic adhesion are supposed to be sufficient to account for the phenomenon without the need to postulate cell type specific adhesion systems: fairly generally accepted, although some tissue specific cell adhesion molecules are now known to exist. (18 Nov 1997) |
| immune adhesion test | The diagnostic application of the immune adhesion phenomenon. Synonym: erythrocyte adherence test, immune adhesion test, red cell adherence test. (05 Mar 2000) |
| interthalamic adhesion | The variable connection between the two thalamic masses across the third ventricle; absent in about 20% of human brains. Synonym: adhesio interthalamica, commissura cinerea, commissura grisea, intermediate mass, massa intermedia. (05 Mar 2000) |
| fibrinous adhesion | An adhesion that consists of fine threads of fibrin resulting from an exudate of plasma or lymph, or an extravasation of blood. (05 Mar 2000) |
| fibrous adhesion | Fibrous strands resulting from the organization of fibrinous adhesion's. (05 Mar 2000) |
| focal adhesion | <cell biology> Areas of close apposition and thus presumably anchorage points, of the plasma membrane of a fibroblast (for example) to the substratum over which it is moving. Usually 1m x 0.2 m with the long axis parallel to the direction of movement, always associated with a cytoplasmic microfilament bundle that is attached via several proteins to the plasma membrane at an area of high protein concentration (this is noticeably electron dense in electron micrographs). Focal adhesions tend to be characteristic of slow moving cells. (18 Nov 1997) |
| leukocyte adhesion deficiency | An inherited disorder (autosomal recessive) in which there is a defective CD18 adherence complex that disturbs leukocyte chemotaxis. It is characterised by recurrent bacterial infections and impaired wound healing. (05 Mar 2000) |
| leukocyte-adhesion deficiency syndrome | <syndrome> Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (receptors, leukocyte-adhesion) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterised by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection. (12 Dec 1998) |
| acquired platelet function defect | <haematology> Platelet function can be affected by a number of different disease processes including polycythaemia vera, leukaemia, myelofibrosis, renal failure, multiple myeloma and some medications (for example penicillins, salicylates, phenothiazines). Disturbed blood clotting can be manifested by: easy bruising, bleeding gums, nosebleeds, abnormal vaginal bleeding, rectal bleeding, skin rash, vomiting blood, coughing up blood or blood in the urine. A measure of bleeding time and coagulation profile will be part of the evaluation. (29 Dec 1997) |
| antigens, human platelet | Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy. (12 Dec 1998) |
| anti-platelet agents | Medications that, like aspirin, reduce the tendency of platelets in the blood to clump and clot. (12 Dec 1998) |
| receptors, platelet-derived growth factor | Specific molecular sites or structures on cell membranes that react with platelet-derived growth factor, its analogs, or antagonists, to elicit or to inhibit the specific response of the cell to this factor. Pdgf binds with different affinities and specificities to two structurally related receptors, the alpha-receptor and the beta-receptor. Both of these receptors are transmembrane proteins with an intracellular, ligand-stimulatable protein kinase domain. (12 Dec 1998) |
| medication, anti-platelet | Platelet-blocking drugs. Drugs that, like aspirin, reduce the tendency of platelets in the blood to clump and clot. (12 Dec 1998) |
| platelet | <haematology> A discoid cell (3m diameter) found in large numbers in blood, important for blood coagulation and for haemostasis by repairing breaches (small breaks) in the walls of blood vessels. Platelet _ granules contain lysosomal enzymes, dense granules contain ADP (a potent platelet aggregating factor) and serotonin (a vasoactive amine). They also release platelet-derived growth factor which presumably contributes to later repair processes by stimulating fibroblast proliferation. Synonym: thrombocytes. (09 Oct 1997) |