| FADS | fetal akinesia deformation sequence |
|---|---|
| FAV | facio-auriculovertebral [sequence]; feline ataxia virus; floppy aortic valve; fowl adenovirus |
| FRHS | fast-repeating high sequence |
| FRV | full-length retroviral [sequence]; functional residual volume |
| IGS | image-guided surgery; inappropriate gonadotropin secretion; internal guide sequence |
| PCR-SSO | Polymerase chain reaction sequence-specific oligonucleotide |
|---|---|
| PCR-SSP | Polymerase chain reaction with sequence specific primers |
| PCR-SSP | Polymerase chain reaction-sequence specific primers |
| PRBS | Pseudorandom binary sequence |
| RSI | Rapid sequence intubation |
| DNA sequence analysis | <molecular biology> Determination of the nucleotide sequence of a length of DNA. Typically, this is performed by cloning the DNA of interest, so that enough can be prepared to allow the sequence to be determined, usually by the Sanger dideoxy chain temination or Maxam Gilbert chain degradation techniques. The resulting reactions are then run on a large sequencing gel, capable of resolving single nucleotide differences in chain length. Recently, PCR based methods have obviated the need to clone the DNA under some conditions and automated DNA sequencing has become widely available. (18 Nov 1997) |
|---|---|
| DNA sequence, unstable | DNA region comprised of a variable number of repetitive, contiguous trinucleotide sequences. Presence of these regions is associated with diseases such as fragile x syndrome and myotonia atrophica. (12 Dec 1998) |
| insertion sequence | Mobile nucleotide sequences that occur naturally in the genomes of bacterial populations. When inserted into bacterial DNA, they inactivate the gene concerned, when they are removed the gene regains its activity. Closely related to transposons and range in size from a few hundred to a few thousand bases, but are usually less than 1500 bases. (18 Nov 1997) |
| intervening sequence | <molecular biology> Alternative but uncommon name for an intron. (18 Nov 1997) |
| tandem repeat sequence | <molecular biology> Multiple copies of the same base sequence on a chromosome, used as a marker in physical mapping. (09 Oct 1997) |
| termination sequence | <molecular biology> The three codons, UAA known as ochre, UAG as amber and UGA as opal, that do not code for an amino acid but act as signals for the termination of protein synthesis. They are not represented by any tRNA and termination is catalysed by protein release factors. There are two release factors in E. Coli, RF1 recognises UAA and UAG, RF2 recognises UAA and UGA. Eukaryotes have a single GTP requiring factor, eRF. See: ochre suppressor, amber suppressor. (13 Jan 1998) |
| enhancer sequence | <molecular biology> A nucleotide sequence, located as many as several thousand base pairs away in either direction from the target gene, which enhances transcription of that gene. (14 Nov 1997) |
| evolutionarily conserved sequence | A base sequence in a DNA molecule (or an amino acid sequence in a protein) that has remained essentially unchanged throughout evolution. (12 Dec 1998) |
| Expressed Sequence Tag | <molecular biology> Expressed sequence tags are sequence tagged sites derived from cDNAs. See: sequence tagged site. Acronym: EST (06 Aug 1998) |
| flanking sequence | <molecular biology> Short DNA sequences bordering a transcription unit. Often these do not code for proteins. (18 Nov 1997) |
| leader sequence | <molecular biology> In the regulation of gene expression for enzymes concerned with amino acid synthesis in prokaryotes, the leader sequence codes for the leader peptide that contains several residues of the amino acid being regulated. Transcription is closely linked to translation and if translation is retarded by limited supply of amino acyl tRNA for the specific amino acid, the mode of transcription of the leader sequence permits full transcription of the operon genes, otherwise complete transcription of the leader sequence prematurely terminates transcription of the operon. (18 Nov 1997) |