| epidemiology, molecular | The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples. (12 Dec 1998) |
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| european molecular biology lab gene bank | <molecular biology> A large database of DNA sequence data in Heidelberg, Germany, compiled from international sources. It is the European equivalent to the Genbank DNA sequence databank in the United States of America. WWW: EMbase. (09 Oct 1997) |
| evolution, molecular | Evolution at the molecular level of DNA sequences and proteins. (rieger et al., glossary of genetics: classical and molecular, 5th ed) (12 Dec 1998) |
| kinetic molecular theory | <chemistry> This theory assumes that molecules must collide in order to react. The more collisions the more likely it is for a reaction to occur. However, depending on the conditions, only a small fraction of the collisions are effective in producing a reaction. There are several constraints. In order for a reaction to occur, bonds initially are broken, which requires energy. This energy depends on the type of the reaction and comes from the kinetic energies that the molecules possess before the collision. It is called the activation energy. Increasing the temperature increases the kinetic energies and more collisions will occur. In adition, at a higher temperature a greater number of the reacting molecules might possess an energy equal to or greater than the activation energy. However the molecules must also collide in a specific orientation, called the steric factor in order for a reaction to occur. A reaction will only be successful, if the collision has enough energy to be either equal to or greater than the activation energy and if the orientation of the collision allows for correct bond formation. These factors are in the Arrhenius equation: k = zp The rate constant k is proportional to the Arrhenius factor A. A is the product of the collision frequency z, and the steric factor p. The fraction of collisions with sufficient energy to produce a reaction are in the term of the equation. (09 Jan 1998) |
| kininogen, high-molecular-weight | A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with prekallikrein. Hmwk is split by plasma kallikrein to produce bradykinin. The complex is a cofactor in the activation of coagulation factor xii. The product of this reaction, xiia, in turn activates prekallikrein to kallikrein. (12 Dec 1998) |
| kininogen, low-molecular-weight | A protein, molecular weight 50 kD, located in various normal tissues. Upon cleavage by kallikrein or other kallikreins, it forms kallidin. Kallidin, in turn, is converted into bradykinin. (12 Dec 1998) |
| A layer | <molecular biology> Right handed double helical DNA with approximately 11 residues per turn. Planes of base pairs in the helix are tilted 20 deg away from perpendicular to the axis of the helix. Formed from B DNA by dehydration. (18 Nov 1997) |
| ameloblastic layer | The internal layer of the enamel organ. Synonym: enamel layer. (05 Mar 2000) |
| anterior elastic layer | A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; considered to be a basement membrane. Synonym: lamina limitans anterior corneae, anterior elastic layer, Bowman's membrane, lamina elastica anterior, limiting layers of cornea. (05 Mar 2000) |
| anterior layer of rectus abdominis sheath | The portion of the rectus sheath that lies anterior to the muscle, consisting in its upper two-thirds of contributions from the aponeuroses of the external and internal oblique muscles, and in its lower third (below the arcuralt line) of contributions from the aponeuroses of all three muscles of the anterolateral abdominal wall. Synonym: lamina anterior vaginae musculi recti abdominis. (05 Mar 2000) |
| anterior limiting layer of cornea | A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; considered to be a basement membrane. Synonym: lamina limitans anterior corneae, anterior elastic layer, Bowman's membrane, lamina elastica anterior, limiting layers of cornea. (05 Mar 2000) |
| bacillary layer | The layer of the retina next to the pigment layer and containing the visual receptors. See: retina, granular layers of retina, neuroepithelial layer of retina. Synonym: bacillary layer. (05 Mar 2000) |
| basal cell layer | The deepest layer of the epidermis, composed of dividing stem cells and anchoring cells. Synonym: basal cell layer, columnar layer, germinative layer, palisade layer, stratum basale, stratum cylindricum, stratum germinativum. (05 Mar 2000) |
| basal layer | The outermost layer of the endometrium which undergoes only minimal changes during the menstrual cycle. Synonym: basal layer. Synonym: stratum basale epidermidis. (05 Mar 2000) |
| basal layer of choroid | The transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina. Synonym: basal lamina of choroid, basal layer of choroid, Bruch's membrane, Henle's membrane, lamina vitrea, vitreous lamella, vitreous membrane. (05 Mar 2000) |