| curative dose | The quantity of any substance required to effect the cure of a disease or that will correct the manifestations of a deficiency of a particular factor in the diet, effective dose used with therapeutically applied compounds. Synonym: therapeutic dose. (05 Mar 2000) |
|---|---|
| preventive dose | The smallest amount of any substance that will prevent occurrence of symptoms of a disease or the consequences of a lack of a particular factor in the diet. (05 Mar 2000) |
| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
| sensitizing dose | In experimental anaphylaxis, the antigenic inoculum that renders an animal susceptible (sensitive) to anaphylactic shock following a subsequent inoculum (shocking dose) of the same antigen (anaphylactogen). (05 Mar 2000) |
| shocking dose | In experimental anaphylaxis, the inoculum of antigen that causes anaphylactic shock in an animal sensitised by a previous inoculum (sensitizing dose) of the same antigen. (05 Mar 2000) |
| skin dose | The quantity of radiation delivered to the skin surface. (05 Mar 2000) |
| daily dose | The total amount of a remedy that is to be taken within 24 hours. (05 Mar 2000) |
| depth dose | The dose of radiation at a distance beneath the surface, including secondary radiation or scatter, in proportion to the dose at the surface. (05 Mar 2000) |
| divided dose | A definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually one day. Synonym: fractional dose. (05 Mar 2000) |
| dose | 1. <pharmacology> A quantity to be administered at one time, such as a specified amount of medication. 2. <radiobiology> A general term denoting the quantity of radiation or energy absorbed. For special purposes it must be appropriately qualified. If unqualified, it refers to absorbed dose. Unit of absorbed dose is the rad. The SI unit is the gray (1 Gy = 1 J kg-1 = 100 R). Origin: Gr. Dosis = a giving (16 Dec 1997) |
| dose-effect curve | This is a graph drawn to show the relationship between the dose of a drug or other chemical and the magnitude of the graded effect that it produces. (09 Oct 1997) |
| dose-escalation | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |
| dose fractionation | Adminstration of the total dose of radiation (radiation dosage) in parts, at timed intervals. (12 Dec 1998) |
| dose intensity | In chemotherapy, the total amount of drug delivered in a one-week period. Can be given all at once or over a period of several days. (16 Dec 1997) |
| dose-ranging | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |