| immunologic tolerance | Lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional. Synonym: immunological tolerance, immunotolerance, nonresponder tolerance. (05 Mar 2000) |
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| impaired glucose tolerance | Blood glucose (sugar) levels higher than normal but not high enough to be called diabetes. People with impaired glucose tolerance may or may not develop diabetes. Other names (no longer used) for impaired glucose tolerance are borderline, subclinical, chemical, or latent diabetes. (30 Mar 1998) |
| individual tolerance | Tolerance to a drug that the person has never received before. (05 Mar 2000) |
| oral lactose tolerance test | A test for lactose deficiency; the plasma glucose response to an oral lactose load is measured as in the (oral) glucose tolerance test. (05 Mar 2000) |
| test, glucose tolerance | After fasting, a specific amount (100 grams) of glucose is given by mouth, and the blood levels of this sugar are measured every hour. Normally, the blood glucose should return to normal within 2 to 2 1/2 hours. The gtt is considered a classic test of carbohydrate metabolism. It is much used in the diagnosis of diabetes. The gtt depends on a number of factors including the ability of the intestine to absorb glucose, the power of the liver to take up and store glucose, the capacity of the pancreas to produce insulin, and the amount of active insulin. (12 Dec 1998) |
| tolerance | 1. The ability to endure unusually large doses of a drug or toxin. 2. Acquired drug tolerance, a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. Origin: L. Tolerantia (18 Nov 1997) |
| tolerance dose | The largest dose of a remedy that can be accepted without the production of injurious symptoms. (05 Mar 2000) |
| exercise tolerance | The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an exercise test. (12 Dec 1998) |
| frustration tolerance | The level of an individual's ability to withstand frustration without developing inadequate modes of response, such as "going to pieces" emotionally. (05 Mar 2000) |