| acyl-CoA oxidase | <enzyme> Catalyses stoichiometric conversion of palmitoyl-CoA and o2 into 2-hexadecenoyl-CoA and h2o2; oxidises acyl-CoA's with carbon chain lengths of 4 to 20; most active toward lauroyl-CoA, but not acetyl- or succinyl-CoA Registry number: EC 1.3.3.6 Synonym: fatty acyl CoA oxidase, fatty acyl-coenzyme a oxidase, fatty acid acyl-CoA oxidase, acox, pox1 gene product (26 Jun 1999) |
|---|---|
| acyl-CoA sterol acyltransferase | <enzyme> Isolated from saccharomyces cerevisiae; sat1 and sat2 are isoenzymes; genbank u55383 Registry number: EC 2.3.1- Synonym: sat1 gene product, sat2 gene product (26 Jun 1999) |
| acyl-CoA synthetase | General term for enzymes that form acyl-CoA, now called ligases, specifically, long-chain fatty acid-CoA ligase. (05 Mar 2000) |
| acyl-CoA transferase | <enzyme> Transfers CoA from succinyl-CoA to propionate, forming propionyl-CoA plus succinate Registry number: EC 2.8.3.- Synonym: propionate CoA-transferase, acyl-coenzyme a transferase (26 Jun 1999) |
| acyl-CoA triterpene acyltransferase | <enzyme> Catalyses the esterification of triterpenes with a fatty acid; requires either acetyl-CoA, ATP, and fatty acid, or fatty acyl-CoA alone Registry number: EC 2.3.1.- Synonym: actt-acyltransferase (26 Jun 1999) |
| alpha-methylacyl-CoA racemase | <enzyme> Involved in catabolism of branched-chain fatty acids derived from isoprenoids; acts on pristanoyl-CoA and trihydroxycoprostanoyl-CoA, but not on 3-methyl branched-chain or linear-chain acyl coas; amino acid sequence has been determined; genbank u89905 (rat) and u89906 (mouse); also isolated from human liver Registry number: EC 5.1.99.- Synonym: meac CoA racemase (26 Jun 1999) |
| aralkyl-CoA-glycine N-acyltransferase | <enzyme> Involved in conjugation of xenobiotics such as substituted benzoic acids or medium chain fatty-acyl-coas with glycine; n-terminal amino acid sequence given in first source Registry number: EC 2.3.1.- Synonym: aralkyltransferase, aralkyl-CoA-glycine n-glycyltransferase (26 Jun 1999) |
| arylacetyl-CoA N-acetyltransferase | <enzyme> Conjugates arylacetic acid derivatives with glycine, glutamine or arginine Registry number: EC 2.3.1.- Synonym: arylacetyl-CoA-amino acid n-acyltransferase (26 Jun 1999) |
| benzoyl-CoA 3-monooxygenase | <enzyme> A fad-dependent hydroxylase that hydroxylates benzoyl-CoA to 3-hydroxybenzoyl-CoA; mw 130 kD (composed of two identical subunits of 56 kD); from denitrifying pseudomonas sp. Registry number: EC 1.14.13.- Synonym: benzoyl-coenzyme a 3-monooxygenase (26 Jun 1999) |
| benzoyl-CoA-anthranilate N-benzoyltransferase | <enzyme> Specific for anthranilate; almost no activity towards 4-hydroxyanthranilate; involved in phytoalexin biosyntesis Registry number: EC 2.3.1.- Synonym: b-CoA-anb transferase, benzoyl-coenzyme a-anthranilate n-benzoyltransferase (26 Jun 1999) |
| beta-hydroxy-beta-methylglutaryl-CoA | -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000) |
| bile acid-CoA ligase | <enzyme> Catalyses the synthesis of all bile acid-coas; in order to measure the activity of all bile acids, the bile acid is coupled with c(14)-glycine and measured with bile acid-CoA glycine-taurine n-acetyltransferase Registry number: EC 6.2.1.- (26 Jun 1999) |
| branched chain acyl-CoA oxidase | <enzyme> Enzyme from human liver peroxisomes acts on both 2-methyl branched fatty acyl- and bile acid-CoA intermediates, unlike rat liver peroxisomes which have separate enzymes for branched chain fatty acids (pristanoyl-CoA) and bile acid-CoA; involved in beta-oxidation of fatty acids and bil Registry number: EC 1.3.3.- Synonym: 2-methyl-branched chain acyl-CoA oxidase, hbrcacox (26 Jun 1999) |
| butyrate-CoA ligase | Fatty acid thiokinase (medium chain), a ligase forming acyl-CoA's from medium-chain fatty acids and CoA with the conversion of ATP to AMP and PPi. A key step in activation of fatty acids. Synonym: acyl-activating enzyme, butyryl-CoA synthetase, octanoyl-CoA synthetase. (05 Mar 2000) |
| butyryl-CoA | CH3CH2CH2COSCoA;condensation product of coenzyme A and n-butanoic acid; an intermediate in fatty acid degradation and in biosynthesis. (05 Mar 2000) |