| malignant melanoma in situ | A melanoma limited to the epidermis and composed of nests of atypical melanocytes and scattered single cells extending into the upper epidermis; local excision is curative although the lesion, if untreated, may soon invade the dermis. Malignant lentigo may be considered a slowly progressive type of malignant melanoma in situ. (05 Mar 2000) |
|---|---|
| malignant melanoma: staging | <radiology> Clark staging: level I: all tumour cells above basement membrane (in situ), level II: tumour extends to papillary dermis, level III: tumour extends to interface between papillary and reticular dermis, level IV: tumour extends between bundles of collagen of reticular dermis, level V: tumour invasion of sucutaneous tissue (87% metastases) Breslow staging: thin: less than 0.75 mm depth of invasion, intermediate: 0.76 - 3.99 mm depth of invasion, thick: greater than 4 mm depth of invasion see: malignant melanoma (12 Dec 1998) |
| malignant meningioma | <tumour> Meningioma that either invades brain parenchyma or metastasizes. (05 Mar 2000) |
| malignant mesothelioma | <oncology, tumour> A mesothelioma is a tumour of the lining of the lung and chest cavity, known as the pleura. Benign mesotheliomas do occur but are much more rare than the malignant type. Malignant mesothelioma affects men more commonly and about 80% of cases have a history for prior exposure to asbestos. Symptoms include chest pain, shortness of breath, cough and weight loss. (27 Sep 1997) |
| malignant midline reticulosis | An obsolete term for polymorphic reticulosis (05 Mar 2000) |
| malignant mixed mullerian tumour | A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. Synonym: malignant mixed mullerian tumour. (05 Mar 2000) |
| malignant mole syndrome | <syndrome> Irregularly shaped, variously coloured, distinctively melanocytic, 5 to 10 mm nevi occurring in large numbers (to over 100) primarily on the trunk and extremities, with a high risk of malignancy reported in several members and three generations of a family. (05 Mar 2000) |
| malignant myopia | pathologic myopia |
| malignant nephrosclerosis | The renal changes in malignant hypertension; subcapsular petechiae, necrosis in the walls of scattered afferent glomerular arterioles, and red blood cells and casts in the urine, with uraemia as a common termination. (05 Mar 2000) |
| malignant oedema | An acute toxaemia of cattle, horses, sheep, goats, and pigs caused by the bacterium Clostridium septicum and characterised by edematous swellings around the entry wound, anorexia, high fever, and death. (05 Mar 2000) |
| malignant pustule | The skin of B. Anthracis infection characteristic lesion that begins as a papule and soon becomes a vesicle and breaks, discharging a bloody serum; the seat of this vesicle, in about 36 hours, becomes a bluish black necrotic mass; constitutional symptoms of septicaemia are severe: high fever, vomiting, profuse sweating, and extreme prostration; the infection is often fatal. Synonym: malignant pustule. (05 Mar 2000) |
| malignant scleritis | Progressive inflammation of the anterior sclera and adjacent choroid with associated uveitis. (05 Mar 2000) |
| malignant smallpox | Malignant smallpox, usually of the haemorrhagic form. Synonym: malignant smallpox. Variola miliaris, a form of varioloid in which the eruption consists of miliary vesicles without the formation of pustules. (05 Mar 2000) |
| malignant stupor | A stuporous condition from which recovery is infrequent, as opposed to benign stupor. (05 Mar 2000) |
| malignant synovioma | <radiology> Soft-tissue mass, usually about 1 cm from joint, amorphous calcifications (33%), most common at knee, bone erosion (wide zone of transition), juxta-articular osteoporosis Cf: pigmented villonodular synovitis (PVS) (12 Dec 1998) |