| juvenile rheumatoid arthritis | <pathology> Juvenile rheumatoid arthritis (JRA) is a form of rheumatoid arthritis in children that generally occurs prior to age 16. In contrast with the adult type, a fever is more pronounced. Cardiac involvement with pericarditis is more common. The arthritis favors one or more large joints and can interfere with normal bone growth. A positive rheumatoid factor is seen more uncommonly in this form of arthritis. Treatment is similar to the adult form of the disease. Up to 75% recover with treatment. Less than 10% are severely disabled by JRA. (27 Sep 1997) |
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| juvenile rheumatoid arthritis, systemic-onset | Also known as systemic-onset juvenile chronic arthritis. Still's disease presents with systemic (bodywide) illness including high intermittent fever, a salmon-coloured skin rash, swollen lymph glands, enlargement of the liver and spleen, and inflammation of the lungs (pleuritis) and around the heart (pericarditis). The arthritis may not be immediately apparent but it does always surface and it may persists long after the systemic symptoms are gone. (12 Dec 1998) |
| juvenile spinal muscular atrophy | Slowly progressive proximal muscular weakness and wasting, beginning in childhood, caused by degeneration of motor neurons in the anterior horns of the spinal cord; onset usually between 2 and 17 years of age; usually autosomal recessive inheritance. Synonym: juvenile muscular atrophy, Kugelberg-Welander disease, Wohlfart-Kugelberg-Welander disease. (05 Mar 2000) |
| juvenile xanthogranuloma | Single or multiple reddish to yellow papules or nodules, usually found in young children, consisting of dermal infiltration by histiocytes and Touton giant cells, with increasing fibrosis. Synonym: nevoxanthoendothelioma. (05 Mar 2000) |
| familial juvenile nephrophthisis | <nephrology> A rare hereditary kidney disease characterised by the gradual loss of kidney function due to the presence of cysts in the renal medulla. Symptoms include high urine output (cannot concentrate the urine), weakness, weight loss, nocturia, fatigue and headache. There is no cure and usually progresses from chronic renal failure to end stage renal disease. (27 Sep 1997) |