| specific immune globulin | Globulin fraction of pooled serums (or plasma) selected for high titre of antibodies specific for a particular antigen, or from persons specifically immunised. (05 Mar 2000) |
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| immune | <immunology> Protected against, infectious disease by either specific or non-specific mechanisms. Origin: L. Immunis = free, exempt (18 Nov 1997) |
| immune adherence | The binding of antigen-antibody complexes or cells coated with antibodies or complement to cells bearing the appropriate complement or Fc receptors. (05 Mar 2000) |
| immune adherence phenomenon | A phenomenon manifested by the adherence of antigen-antibody-complement complex to "indicator cells" (microorganisms, platelets, leukocytes, or erythrocytes), the reaction being sensitive and specific for the antigen and antibody in the complex. Synonym: erythrocyte adherence phenomenon, immune adherence phenomenon, red cell adherence phenomenon. (05 Mar 2000) |
| immune adherence reaction | A method for the detection of very small quantities of antibody in which the antigen-antibody-complement complex adheres to indicator cells, usually primate erythrocytes or nonprimate blood platelets. The reaction is dependent on the number of bound c3 molecules on the c3b receptor sites of the indicator cell. (12 Dec 1998) |
| immune adhesion test | The diagnostic application of the immune adhesion phenomenon. Synonym: erythrocyte adherence test, immune adhesion test, red cell adherence test. (05 Mar 2000) |
| immune adsorption | Removal of antibody (agglutinin or precipitin) from antiserum by use of specific antigen; after aggregation has occurred, the antigen-antibody complex is separated either by centrifugation or by filtration, removal of antigen by specific antiserum in a similar manner. (05 Mar 2000) |
| immune agglutination | Agglutination caused by antibody (agglutinin) that is specific for the suspended microorganism, cell, or for an antigen that has been coated on a particle of suitable size. (05 Mar 2000) |
| immune agglutinin | 1. An antibody that causes clumping or agglutination of the bacteria or other cells which either stimulated the formation of the agglutinin, or contain immunologically similar, reactive antigen. Synonym: agglutinating antibody, immune agglutinin. 2. A substance, other than a specific agglutinating antibody, that causes organic particles to agglutinate, commonly qualified, e.g., plant agglutinin. (05 Mar 2000) |
| immune complex | <immunology> Multimolecular antibody antigen complexes that may be soluble or insoluble depending upon their size and whether or not complement is present. Immune complexes can be filtered from plasma in the kidney and the deposition of the complexes gives rise to glomerulonephritis probably because of the trapping of neutrophils via their Fc receptors. (18 Nov 1997) |
| immune complex disease | An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis. See: autoimmune disease. Synonym: immune complex disorder, type III hypersensitivity reaction. (05 Mar 2000) |
| immune complex diseases | Diseases characterised by the presence of immune complexes in body fluids. Hypersensitivity of the Arthus type and serum sickness are examples. (18 Nov 1997) |
| immune complex disorder | An immunologic category of diseases evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue disease's, may belong in this immunologic category; immune complex disease's can also occur during a variety of disease's of known aetiology, such as subacute bacterial endocarditis. See: autoimmune disease. Synonym: immune complex disorder, type III hypersensitivity reaction. (05 Mar 2000) |
| immune complex glomerulonephritis | Immune complexes are deposited in the renal glomerulus where they bind complement and initiate an inflammatory process attracting neutrophils and macrophages resulting in an alteration of the basement layer of the kidney. The disease state can lead to ultimate destruction of the glomerulus and renal failure. (05 Mar 2000) |
| immune complex nephritis | An immune complex disease resulting from glomerular deposits, as in systemic lupus erythematosus. (05 Mar 2000) |