| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| 영문 | Electric convulsive therapy(ECT) | 한글 | 전기경련요법 |
|---|---|---|---|
| 설명 | 뇌에 전기 자극을 주어 인위적으로 경련을 유발함으로써 정신 병을 치료하는 방법. 전기쇼크요법(electroshock therapy)이라고도 한다. 1938년에 이탈리아의 체를레티와 비니에 의해 시작되었다. 작용기전은 확실치 않으나 뇌의 신진대사, 생화학 및 효소 등에 변화를 일으킨다는 생물학적, 생화학적 학설이 유력하다. 적응증으로 가장 효과적인 병은 우울증으로 특히 여성에서 갱년기에 호발하는 갱년기 우울증, 우울증과 조증(아주 기분이 좋은 상태가 지속되는 정신병)이 일정한 주기를 두고 반복하는 조울증에 잘 쓰이며, 80~90%에서 효과가 있다. |
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| gene therapy | <molecular biology> Treatment of a disease caused by malfunction of a gene, by stably transfecting the cells of the organism with the normal gene. (18 Nov 1997) |
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| receptors, corticotropin-releasing hormone | Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behaviour of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood. (12 Dec 1998) |
| receptors, gastrointestinal hormone | Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behaviour of cells. most gastrointestinal hormones also act as neurotransmitters so these receptors are also present in the central and peripheral nervous systems. (12 Dec 1998) |
| receptors, pancreatic hormone | Cell surface proteins that bind pancreatic hormones with high affinity and trigger intracellular changes which influence the behaviour of cells. These include receptors for glucagon (secreted by alpha cells), insulin (secreted by beta cells), somatostatin (secreted by delta cells), and pancreatic peptide (secreted by pp cells). Some of these hormones and receptors also support neurotransmission. (12 Dec 1998) |
| receptors, parathyroid hormone | Cell surface proteins that bind parathyroid hormone with high affinity and trigger intracellular changes which influence the behaviour of cells. Parathyroid hormone receptors on bone, kidney, and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis. (12 Dec 1998) |
| receptors, pituitary hormone | Cell surface proteins that bind pituitary hormones with high affinity and trigger intracellular changes influencing the behaviour of cells. Since many pituitary hormones are also released by neurons as neurotransmitters, these receptors are also found in the nervous system. (12 Dec 1998) |
| receptors, thyroid hormone | Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erba, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erba proteins act as growth suppressors. The c-erba proteins are encoded by at least two genes, c-erba alpha and c-erba beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes thyroid hormone resistance syndrome. (12 Dec 1998) |
| receptors, thyrotropin-releasing hormone | Cell surface receptors that bind thyrotropin releasing hormone (trh) with high affinity and trigger intracellular changes which influence the behaviour of cells. Activated trh receptors in the anterior pituitary stimulate the release of thyrotropin (thyroid stimulating hormone, tsh). Trh receptors on neurons mediate neurotransmission by trh. (12 Dec 1998) |
| parathyroid hormone | <hormone> A peptide hormone of 84 amino acids (9402 D). Stimulates osteoclasts to increase blood calcium levels, the opposite effect to calcitonin. (18 Nov 1997) |
| marital therapy | A form of psychotherapy involving the husband and wife and directed to improving the marital relationship. (12 Dec 1998) |
| marriage therapy | A type of family therapy that involves both husband and wife and focuses on the marital relationship as it affects the individual personalities, behaviours, and psychopathologies of the partners; the rationale for this method is the assumption that emotional or psychopathological processes within the family structure and in the social matrix of the marriage perpetuate individual pathological personality structures, which find expression in the disturbed marriage and are aggravated by the feedback between partners. Synonym: marital therapy. (05 Mar 2000) |
| parenteral therapy | Therapy introduced usually by a needle through some other route than the alimentary canal. (05 Mar 2000) |
| geriatric therapy | Treatment of disease in the aged. Synonym: geriatric therapy. (05 Mar 2000) |
| germ line gene therapy | The repair or replacement of a defective gene within the gamete-forming tissues, which produces an inheritable change in an organisms genetic constitution. (09 Oct 1997) |
| gestalt therapy | A form of psychotherapy with emphasis on the interplay of organism and environment. Basic to this therapy is the development of awareness and maturity, as well as self-confidence. (12 Dec 1998) |