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giant cell reparative g., peripheral giant cell epulis.
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giant cell s. 1. a form of giant cell tumor of bone (q.v.) that arises malignant de novo, rather than transforming to malignancy.  2. sarcoma characterized by large anaplastic (giant) cells.
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giant cell t. subacute granulomatous t.
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giant cell t. of bone a bone tumor composed of cellular spindle cell stroma containing scattered multinucleated giant cells resembling osteoclasts; symptoms may include local pain and tenderness, functional disability, and, occasionally, pathologic fractures. The tumors remain benign or progress to frankly malignant lesions. See also giant cell sarcoma, under sarcoma. Called also osteoclastoma.
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giant cell t. of tendon sheath a benign tumor-like lesion of tendon sheath origin forming a small, yellow, discrete nodule, most commonly of the wrist and fingers, or ankle and toes; the tissue is laden with lipophages and contains multinucleated giant cells. It is sometimes considered a variant or subtype of benign fibrous histiocytoma (q.v). Called also benign synovioma and nodular tenosynovitis.
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