| diffuse angiokeratoma | <disease> Lysosomal storage disease caused by a deficiency of alpha-galactosidase a and resulting in an accumulation of globotriaosylceramide in the renal and cardiovascular systems. The disease is characterised by telangiectatic skin lesions, renal failure, and disturbances of the cardiovascular, gastrointestinal, and central nervous systems. Inheritance: x-linked. (08 Mar 2000) |
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| diffuse arterial ectasia | Spontaneous enlargement with dilation of the vessels in a circumscribed area. (05 Mar 2000) |
| diffuse brain atrophy | A form of dementia caused by destruction (atrophy) of the frontal lobes of the brain. This condition leads to the progressive deterioration of mental functioning. Incidence: 9 in 10,000 people in the general population. (27 Sep 1997) |
| diffuse choroiditis | A widespread exudative inflammation of the choroid, with progressive resolution of older lesions as new ones occur. (05 Mar 2000) |
| diffuse cutaneous leishmaniasis | Leishmaniasis caused by several New and Old World species and strains of Leishmania (L. Mexicana amazonensis, L. M. Pifanoi, possibly L. M. Garnhami and L. M. Venezuelensis; in Ethiopia, L. Aethiopica, and unidentified leishmanial agents in Namibia and Tanzania). The condition is associated with a suppressed cell-mediated immune response, so that the non-ulcerating, non-necrotizing cutaneous lesions can spread widely over the body; great numbers of parasite-filled macrophages are found in the dermal lesions. Healing does not appear to occur unless an acquired cellular hypersensitivity can develop. Synonym: anergic leishmaniasis, diffuse leishmaniasis, disseminated cutaneous leishmaniasis, leishmaniasis tegumentaria diffusa, pseudolepromatous leishmaniasis. (05 Mar 2000) |
| diffuse cutaneous mastocytosis | A benign process consisting of focal cutaneous infiltrates composed of mast cells; lesions are flat or slightly elevated, form wheals and itch when stroked; bone lesions may occur. Synonym: urticaria pigmentosa. (05 Mar 2000) |
| diffuse deep keratitis | An inflammation of the posterior corneal stroma. Synonym: diffuse deep keratitis. (05 Mar 2000) |
| diffuse emphysema | Emphysema affecting all parts of the lobules, in part, or usually the whole, of the lungs, and usually associated with a1-antiprotease deficiency emphysema. Synonym: diffuse emphysema, generalised emphysema, panacinar emphysema. (05 Mar 2000) |
| diffuse gallbladder wall thickening | <radiology> Criterion: gall bladder wall greater than 3 mm may appear thicker due to surrounding ascites, cholecystitis (acute or chronic), non-fasting state, chronic hypoalbuminaemia, hepatitis, congestive heart failure, fat in gall bladder fossa Cf: focal thickening (12 Dec 1998) |
| diffuse ganglion | A cystic swelling due to inflammatory effusion into one or several adjacent tendon sheaths. (05 Mar 2000) |
| diffuse glomerulonephritis | Glomerulonephritis affecting most of the renal glomeruli; it may lead to azotemia. (05 Mar 2000) |
| diffuse goiter | Goiter in which the morbid process involves the whole gland, as opposed to nodular goiter or thyroid adenoma. (05 Mar 2000) |
| diffuse idiopathic skeletal hyperostosis | A form of degenerative arthritis characteristically associated with flowing calcification along the sides of the vertebrae of the spine and commonly with inflammation (tendinitis) and calcification of the tendons at their attachments points to bone. Because areas of the spine and tendons can become inflamed, antiinflammatory medications (NSAIDs), such ibuprofen, can be helpful in both relieving pain and inflammation. Also called Forestier's disease. (12 Dec 1998) |
| diffuse infantile familial sclerosis | <radiology> Dysmyelinating disease, autosomal recessive, usually presents by 1 yr, specific enzyme deficiency identified, rapid spontaneous nystagmus, poikilothermia Synonym: Krabbe leukodystrophy (12 Dec 1998) |
| diffuse interstitial fibrosis | Progressive fibrous changes and scarring within the lung tissue, eventually interfering with normal gas exchange. (27 Sep 1997) |